EFFECTS OF GENETIC AND NUTRITIONAL FACTORS ON POST NATAL REFLEX AND BEHAVIORAL DEVELOPMENT IN THE MOUSE
EFFECTS OF GENETIC AND NUTRITIONAL FACTORS ON POST NATAL REFLEX AND BEHAVIORAL DEVELOPMENT IN THE MOUSE
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DOI：
10.1080/03610737508257945
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发表时间：
1975-01-01
影响因子：
1.8
通讯作者：
ALLEGRA S P
中科院分区：
文献类型：
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作者：
OLIVERIO A;CASTELLANO C;ALLEGRA S P
在属于Swiss-Webster品系和2个近交系（C57 BL/6 J和SEC/1 Re）的小鼠中，在从出生到成熟的不同年龄评估了一些反射活动、皮层脑电图（ECoG）以及脑和体重测量的发展。还在60日龄时测试动物的探索活动和回避行为。出生后营养不良的反射和ECoG活动，大脑和体重和回避学习的措施，这些影响在出生后的不同年龄和成年动物的饮食康复。通过将每窝产仔数从4只幼崽增加到8或16只幼崽，在哺乳期引入营养不良。结果表明，早期营养不良延迟了反射和ECoG活动的发展，并永久改变了大脑的生长和回避学习。影响是不同的，这取决于所考虑的基因型。这些数据表明，以脑功能发育较慢为特征的菌株在营养不良后不会显示出脑功能障碍的早期迹象。
The development of a number of reflex activities, of the electrocorticogram (ECoG), and measures of brain and body weight were assessed at different ages from birth to maturity in mice belonging to Swiss-Webster stock and 2 inbred strains (C57BL/6J and SEC/1Re). The animals also were tested at 60 days of age for exploratory activity and avoidance behavior. These effects of postnatal undernutrition on the measures of reflex and ECoG activity, brain and body weight and avoidance learning were determined at different ages after birth and in adult animals following dietary rehabilitation. Undernutrition during suckling period was introduced by increasing the litter size from 4 pups to 8 or 16 pups per litter. The results indicate that early malnutrition delayed the development of the reflex and ECoG activities and permanently altered brain growth and avoidance learning. The effects were different, depending on the genotype considered. The data indicate that strains characterized by a slower development of brain function do not show early signs of brain malfunction following undernutrition.