Open channel-based microchip electrophoresis interfaced with mass spectrometry via electrostatic spray ionization
Open channel-based microchip electrophoresis interfaced with mass spectrometry via electrostatic spray ionization
复制标题
基于开放通道的微芯片电泳通过静电喷雾电离与质谱联用
DOI：
10.1016/j.cclet.2015.09.017
复制
发表时间：
2016-01-01
影响因子：
9.1
通讯作者：
Girault, Hubert H.
中科院分区：
文献类型：
--
作者：
Deng, Yan;Qiao, Lang;Girault, Hubert H.
The coupling between open channel-based microchip electrophoresis and mass spectrometry via electrostatic spray ionization is proposed for in situ detection of fractionated analytes. Electrophoretic separation is performed in an open channel fabricated in a plastic substrate. The solvent of background electrolyte is evaporated from the open channel because of Joule heating during electrophoresis, leaving the dried-electrophoretic bands to be directly analyzed by mass spectrometry via scanning electrostatic spray ionization. Proof-of-concept results are obtained with fluorescent dyes and antibiotics as the test samples, demonstrating an efficient on-chip detection platform based on the electrophoresis and electrostatic spray ionization mass spectrometry. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
