Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate
Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate
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DOI：
10.1016/s0304-3835(98)00084-6
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发表时间：
1998-08-14
期刊：
影响因子：
9.7
通讯作者：
Young, CYF
中科院分区：
文献类型：
--
作者：
Paschka, AG;Butler, R;Young, CYF
绿色茶成分具有多种生物学效应，包括抗肿瘤和预防癌症的活性。在寻找用于前列腺癌的抗癌剂的过程中，测试了绿色茶组分对前列腺癌细胞系LNCaP、PC-3和DU 145的抑制作用。（-）-表儿茶素没食子酸酯（EGCG）被证明是抑制细胞生长的最有效的儿茶素。通过细胞核形态学和DNA片段化的变化，发现由EGCG诱导的抑制通过凋亡细胞死亡发生。因此，我们报告的第一个证据表明，表没食子儿茶素没食子酸酯是绿色茶中的活性成分，并诱导人前列腺癌细胞凋亡。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
Green tea components exert many biological effects, including antitumor and cancer preventive activities. In the search for anticancer agents for prostate cancer the inhibitory effects of green tea components were tested on the prostate cancer cell lines LNCaP, PC-3 and DU145. (-)-Epigatlocatechin-3-gallate (EGCG) proved to be the most potent catechin at inhibiting cell growth. The inhibition induced by EGCG was found to occur via apoptotic cell death as shown by changes in nuclear morphology and DNA fragmentation. Thus, we report the first evidence that EGCG is the active component in green tea and induces apoptosis in human prostate cancer cells. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.