Anti-inflammatory meroterpenoids from the mangrove endophytic fungus Talaromyces amestolkiae YX1
Anti-inflammatory meroterpenoids from the mangrove endophytic fungus Talaromyces amestolkiae YX1
复制标题
来自红树林内生真菌 Talaromyces amestolkiae YX1 的抗炎类萜。
DOI：
10.1016/j.phytochem.2017.11.011
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发表时间：
2018-02-01
期刊：
影响因子：
3.8
通讯作者：
She, Zhigang
中科院分区：
文献类型：
--
作者：
Chen, Senhua;Ding, Meng;She, Zhigang
从小麦固体培养基上培养的红树林内生真菌Talaromyces amestolkiae YX 1中分离得到4个未报道的部分萜类化合物amestolkolides A-D，沿着3个已知化合物。它们的结构通过光谱分析的组合进行了鉴定。的绝对构型amestolkolides B和C，和purpurogenetine E的单晶X-射线衍射使用铜K α辐射，和amestolkolides A和D的实验和计算的电子圆二色光谱的基础上阐明。amestolkolides A-D和purpurogenolide E（9 R）在C-9位的绝对构型与文献中类似物（9 S）不同，因此提出了它们可能的独特的生物合成途径。通过抑制RAW 264.7细胞中活化的脂多糖中一氧化氮（NO）的产生，Amestolklatin B显示出较强的体外抗炎活性，IC 50值为1.6 +/- 0.1 μ M。(C)2017爱思唯尔有限公司版权所有
Four previously undescribed meroterpenoids, amestolkolides A-D, along with three known compounds were isolated from the mangrove endophytic fungus Talaromyces amestolkiae YX1 cultured on wheat solid-substrate medium culture. Their structures were elucidated by a combination of spectroscopic analyses. The absolute configurations of amestolkolides B and C, and purpurogenolide E were determined by single-crystal X-ray diffraction using Cu K alpha radiation, and those of amestolkolides A and D were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. The absolute configuration of amestolkolides A-D, and purpurogenolide E (9R) at C-9 was different from that of analogues (9S) in references, so that their plausible and distinct biosynthetic pathways were proposed. Amestolkolide B showed strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide activated in RAW264.7 cells with IC50 value of 1.6 +/- 0.1 mu M. (C) 2017 Elsevier Ltd. All rights reserved.