Blood cytokine levels rise even after minor surgical trauma
Blood cytokine levels rise even after minor surgical trauma
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DOI：
10.1007/bf01540914
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发表时间：
1996-05-01
影响因子：
9.1
通讯作者：
Rowinski, W
中科院分区：
文献类型：
--
作者：
Grzelak, I;Olszewski, WL;Rowinski, W
手术创伤后细胞因子产生的确切变化以及细胞因子水平增加的临床意义仍不清楚。在这项研究中，在经历轻微选择性手术创伤的患者中检查了一系列细胞因子的全身产生，包括 IL1 α、IL1 β、IL6、IL8、IL10 和 IFN γ。还测定了IL1受体拮抗剂(ra)和IL6可溶性受体(sR)的水平。尽管在整个观察期间IL1α和IL1β血浆水平没有变化，但术后第1天至术后第14天，所有患者的IL1、ra水平显着升高。术后第1、3和7天观察到IL6血浆水平显着升高，术后第10和14天观察到IL6 sR水平升高。有趣的是，术后第1和3天IL8血浆值显着升高操作。在一些患者中，术后第 1 天和第 3 天发现血浆 IL10 水平升高。结果表明，即使是小手术，例如胆囊切除术，伤口愈合顺利，术后第 1 天到第 14 天之间，血液循环中也会出现显着水平的细胞因子。这些观察结果表明，有必要寻找下调手术创伤后全身细胞因子效应的方法，以进行常规术后管理。
The exact changes in cytokine production and clinical implications of the increased cytokine levels following operative trauma remain unclear. In this study, systemic production of a spectrum of cytokines, including IL1 alpha, IL1 beta, IL6, IL8, IL10, and IFN gamma, was examined in patients undergoing minor elective operative trauma. The levels of IL1 receptor antagonist (ra) and IL6 soluble receptor (sR) were also determined. Although there were no changes in IL1 alpha and IL1 beta plasma levels during the entire observation period, there was a significant rise in IL1, ra level in all patients between postoperative day 1 and postoperative day 14. A significant increase in the IL6 plasma level was seen on days 1, 3, and 7 after surgery and an increase in the IL6 sR level was observed on postoperative days 10 and 14. Interestingly, the IL8 plasma values had risen significantly on days 1 and 3 following the operation. In some patients, an elevation in IL10 plasma level was noted on days 1 and 3 postsurgery. Results demonstrated that even a minor surgical procedure such as cholecystectomy with uneventful wound healing was followed by an appearance in the blood circulation of significant levels of cytokines between day 1 and day 14 after surgery. These observations point to the necessity of searching for methods of down-regulating the systemic cytokine effects after surgical trauma for the routine postoperative management.