The role of hydrogen translocating shuttles during ethanol oxidation in hepatocytes from euthyroid and hyperthyroid rats.
The role of hydrogen translocating shuttles during ethanol oxidation in hepatocytes from euthyroid and hyperthyroid rats.
复制标题
甲状腺功能正常和甲状腺功能亢进大鼠肝细胞乙醇氧化过程中氢易位穿梭的作用。
DOI：
10.1111/j.1432-1033.1980.tb04693.x
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
A. Meijer
中科院分区：
文献类型：
--
作者：
L. Hensgens;B. Nieuwenhuis;R. van der Meer;A. Meijer
在甲状腺功能正常和甲状腺功能亢进大鼠的肝细胞中，对乙醇氧化过程中苹果酸-天冬氨酸和甘油-3-磷酸循环对还原当量从细胞质到线粒体的易位的贡献进行了定量研究。1.在甲状腺功能正常大鼠的肝细胞中，两个循环的容量几乎相等，它们对总氢转运到线粒体的相对贡献取决于所选择的条件。2.在甲状腺功能亢进大鼠的肝细胞中，乙醇氧化的最大速率显着低于甲状腺功能正常大鼠的肝细胞，即使甘油-3-磷酸循环的能力增加。这是由于乙醇脱氢酶的活性降低。
A quantitative study of the contribution of the malate-aspartate and glycerol-3-phosphate cycles to the translocation of reducing equivalents from cytosol to mitochondria during ethanol oxidation has been made in hepatocytes from euthyroid and hyperthyroid rats. 1. In hepatocytes from euthyroid rats both cycles have an almost equal capacity and their relative contribution to total hydrogen transport to the mitochondria depends on the conditions chosen. 2. In hepatocytes from hyperthyroid rats maximal rates of ethanol oxidation were significantly lower than in hepatocytes from euthyroid rats, even though the capacity of the glycerol-3-phosphate cycle was increased. This was due to a decreased activity of alcohol dehydrogenase.