The regulation of differentiation in murine virus-induced erythroleukemic cells.
The regulation of differentiation in murine virus-induced erythroleukemic cells.
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鼠病毒诱导的红白血病细胞分化的调节。
DOI：
10.1007/978-3-540-38267-6_26
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发表时间：
1980
影响因子：
--
通讯作者：
Friend,C
中科院分区：
文献类型：
--
作者：
Friend,C
来源于Friend病毒诱导白血病小鼠脾脏的连续红白血病细胞系提供了一个方便的实验系统，在该系统中可以详细检查红细胞分化的分子控制（Friend et al. 1966; Ikawa and Sugano 1966; Ostertag et al. 1972; Freedman and Lilly 1975）。培养物含有处于不同分化阶段的细胞。大多数是大的原始红系细胞，具有突出的核仁，但也存在少数可识别为正常成红细胞的成熟细胞。我们开发这些细胞系的想法是将白血病作为一种由成熟障碍引起的疾病进行研究，并希望找到刺激细胞分化的方法。在某种程度上，我们实现了这个目标。
Continuous lines of erythroleukemia cells, which originate from the spleens of mice with Friend virus-induced leukemia, provide a convenient experimental system in which the molecular control of erythrodifferentiation can be examined in some detail (Friend et al. 1966; Ikawa and Sugano 1966; Ostertag et al. 1972; Freedman and Lilly 1975). The cultures contain cells at various stages of differentiation. The majority are large, primitive erythroid cells with prominent nucleoli, but a few more mature cells recognizable as normoblasts are present. We had developed these lines with the idea of studying leukemia as a disease resulting from a block in maturation, and had hoped to find means of stimulating the cells to differentiate. To a certain extent, we achieved this goal.