The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us
The subiculum: what it does, what it might do, and what neuroanatomy has yet to tell us
复制标题
DOI：
10.1111/j.1469-7580.2005.00446.x
复制
发表时间：
2005-09-01
影响因子：
2.4
通讯作者：
O'Mara, S
中科院分区：
文献类型：
--
作者：
O'Mara, S
下托是一个关键的，但研究不足的结构之间的海马适当和内嗅和其他皮质，以及一系列的皮质下结构。下托具有一系列与其输入区域截然不同的电生理和功能特性;考虑到它与广泛的皮质和皮质下区域相互作用，它能够影响完全不同的大脑区域的活动。支配海马-下托轴中突触传递可塑性的规则知之甚少;该轴似乎与海马体本身具有某些共同的特性，但在其他方面表现得非常不同。同样，它的功能特性也没有得到很好的理解;它在空间导航、记忆处理和对压力反应的控制方面发挥着重要但不明确的作用。在这里，我回顾调查的突触可塑性在海马下托通路，记录下托神经元在自由移动的行为动物，行为和其他应激源的影响下托突触可塑性，和解剖数据的背腹组织的下托有关下丘脑-垂体-肾上腺（HPA）轴。我认为，有一个背腹分离的功能内的下托：背侧组件似乎主要关注的空间，运动和记忆的信息处理，而腹侧组件似乎发挥了重要的调节作用，在抑制HPA轴。
The subiculum is a pivotal but under-investigated structure positioned between the hippocampus proper and entorhinal and other cortices, as well as a range of subcortical structures. The subiculum has a range of electrophysiological and functional properties which are quite distinct from its input areas; given the widespread set of cortical and subcortical areas with which it interacts, it is able to influence activity in quite disparate brain regions. The rules governing plasticity of synaptic transmission in the hippocampal-subicular axis are poorly understood; this axis appears to share some properties in common with the hippocampus proper, but behaves quite differently in other respects. Equally, its functional properties are not well understood; it plays an important but ill-defined role in spatial navigation, mnemonic processing and control of the response to stress. Here, I review investigations of synaptic plasticity in the hippocampal-subicular pathway, recordings of subicular neurons in the freely moving behaving animal, the effects of behavioural and other stressors on subicular synaptic plasticity, and anatomical data on the dorso-ventral organization of the subiculum in relation to the hypothalamic-pituitary-adrenal (HPA) axis. I argue that there is a dorso-ventral segregation of function within the subiculum: the dorsal component appears principally concerned with the processing of information about space, movement and memory, whereas the ventral component appears to play a major regulatory role in the inhibition of the HPA axis.