High prevalence of Nova hantavirus infection in the European mole (Talpa europaea) in France
High prevalence of Nova hantavirus infection in the European mole (Talpa europaea) in France
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DOI：
10.1017/s0950268813002197
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发表时间：
2014-06-01
影响因子：
4.2
通讯作者：
Yanagihara, R.
中科院分区：
文献类型：
--
作者：
Gu, S. H.;Dormion, J.;Yanagihara, R.
最近发现的遗传上不同的汉坦病毒在鼠和鼹鼠（Soricomorpha，家庭Soricidae和Talpidae）提出了挑战的传统观点，啮齿动物作为主要的水库主机。诺瓦病毒（NVAV），以前确定的档案肝脏组织的一个单一的欧洲鼹鼠（Talpa europaea）从匈牙利，代表了最高度分歧汉坦病毒确定的日期。为了确定NVAV的空间分布和遗传多样性，我们采用RT-PCR分析了2012年10月至2013年3月期间在法国两个地点捕获的94只鼹鼠的肺。在每个位置的60%以上的摩尔中检测到NVAV，表明有效的地方病病毒传播，并确认这种摩尔物种作为水库主机。虽然NVAV的致病潜力尚不清楚，但欧洲鼹鼠的广泛地理分布可能对人类构成汉坦病毒暴露风险。
Recent discovery of genetically distinct hantaviruses in shrews and moles (order Soricomorpha, family Soricidae and Talpidae) has challenged the conventional view that rodents serve as the principal reservoir hosts. Nova virus (NVAV), previously identified in archival liver tissue of a single European mole (Talpa europaea) from Hungary, represents one of the most highly divergent hantaviruses identified to date. To ascertain the spatial distribution and genetic diversity of NVAV, we employed RT-PCR to analyse lungs from 94 moles, captured in two locations in France, during October 2012 to March 2013. NVAV was detected in more than 60% of moles at each location, suggesting efficient enzootic virus transmission and confirming that this mole species serves as the reservoir host. Although the pathogenic potential of NVAV is unknown, the widespread geographical distribution of the European mole might pose a hantavirus exposure risk for humans.