Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial
Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial
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DOI：
10.1016/j.jhep.2021.02.027
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发表时间：
2021-06-15
影响因子：
25.7
通讯作者：
Gerber, Philipp A.
中科院分区：
文献类型：
--
作者：
Geidl-Flueck, Bettina;Hochuli, Michel;Gerber, Philipp A.
背景与目的：过量果糖摄入与新生脂肪生成、血甘油三酯和肝胰岛素抵抗增加有关。我们的目的是确定是否果糖elevin的具体影响脂质代谢独立的过量的热量intake.Methods：共94名健康男性进行了研究，在这个双盲，随机试验。他们被分配到每天消费的含糖饮料（SSB）含有适量的果糖，蔗糖（果糖-葡萄糖二糖）或葡萄糖（80克/天），除了他们的日常饮食或SSB禁欲（对照组）7周。结果：每天摄入含游离果糖和果糖与葡萄糖（蔗糖）结合的甜味饮料导致基础肝脏部分分泌率（FSR）比对照组增加2倍（中值FSR %/天：蔗糖20.8（p = 0.0015）;果糖19.7（p = 0.013）;对照9.1）。相反，相同量的葡萄糖不会改变FSR（中位数FSR %/天11.0（n.s.））。果糖摄入量并没有改变基础分泌的新合成的VLDL-甘油三酯，也没有改变率外周脂解，也没有总脂肪酸和血浆游离脂肪酸氧化。总能量摄入量是相似的groups.Conclusions：经常消费的果糖和蔗糖加糖饮料在中等剂量-与稳定的热量摄入-增加肝脏脂肪酸的合成，即使在基础状态，这种效果是没有观察到葡萄糖消费后。这些研究结果提供了证据的适应性反应，定期果糖暴露在liver.Lay摘要：这项研究调查了几个星期的日常含糖饮料消费的代谢影响，在健康的瘦男性。研究表明，含有果糖和蔗糖（葡萄糖和果糖的组合）而不是葡萄糖的饮料会增加肝脏产生脂质的能力。这种变化可能会为对代谢健康的进一步不利影响铺平道路。(C)2021作者由Elsevier B. V.代表欧洲肝脏研究协会发表。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Background & aims: Excessive fructose intake is associated with increased de novo lipogenesis, blood triglycerides, and hepatic insulin resistance. We aimed to determine whether fructose elicits specific effects on lipid metabolism independently of excessive caloric intake.Methods: A total of 94 healthy men were studied in this double-blind, randomized trial. They were assigned to daily consumption of sugar-sweetened beverages (SSBs) containing moderate amounts of fructose, sucrose (fructose-glucose disaccharide) or glucose (80 g/day) in addition to their usual diet or SSB abstinence (control group) for 7 weeks. De novo fatty acid (FA) and triglyceride synthesis, lipolysis and plasma free FA (FFA) oxidation were assessed by tracer methodology.Results: Daily intake of beverages sweetened with free fructose and fructose combined with glucose (sucrose) led to a 2-fold increase in basal hepatic fractional secretion rates (FSR) compared to control (median FSR %/day: sucrose 20.8 (p = 0.0015); fructose 19.7 (p = 0.013); control 9.1). Conversely, the same amounts of glucose did not change FSR (median of FSR %/day 11.0 (n.s.)). Fructose intake did not change basal secretion of newly synthesized VLDL-triglyceride, nor did it alter rates of peripheral lipolysis, nor total FA and plasma FFA oxidation. Total energy intake was similar across groups.Conclusions: Regular consumption of both fructose- and sucrose-sweetened beverages in moderate doses - associated with stable caloric intake - increases hepatic FA synthesis even in a basal state; this effect is not observed after glucose consumption. These findings provide evidence of an adaptative response to regular fructose exposure in the liver.Lay summary: This study investigated the metabolic effects of daily sugar-sweetened beverage consumption for several weeks in healthy lean men. It revealed that beverages sweetened with the sugars fructose and sucrose (glucose and fructose combined), but not glucose, increase the ability of the liver to produce lipids. This change may pave the way for further unfavorable effects on metabolic health. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).