Membrane transport of hydrogen peroxide
Membrane transport of hydrogen peroxide
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DOI：
10.1016/j.bbamem.2006.02.015
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发表时间：
2006-08-01
影响因子：
3.4
通讯作者：
Jahn, Thomas P.
中科院分区：
文献类型：
--
作者：
Bienert, Gerd P.;Schjoerring, Jan K.;Jahn, Thomas P.
过氧化氢（H2O2）属于活性氧（ROS），被称为氧化剂，可以与各种细胞靶标发生反应，从而导致细胞损伤甚至细胞死亡。另一方面，最近的研究表明，H2O2 还可以作为控制植物和哺乳动物不同基本过程的信号分子。由于这些相反的功能，H 2 O 2 的细胞水平可能通过涉及生产、分配和去除的过程受到严格调节。在探索 H2O2 的形成和清除方面已经取得了实质性进展，但对于这种信号分子如何从其起源部位转运到作用或解毒部位却知之甚少。从酵母和细菌的研究中可以清楚地看出，H2O2 跨膜的扩散是有限的。我们现在获得的直接证据表明，来自植物和哺乳动物的选定水通道蛋白同系物具有引导 H2O2 跨膜的能力。本综述的主要重点是 (i) 总结 H2O2 在植物和哺乳动物的各种途径中信号传导作用的最新证据，以及 (ii) 讨论 H2O2 特定转运的相关性。 (c) 2006 Elsevier B.V. 保留所有权利。
Hydrogen peroxide (H2O2) belongs to the reactive oxygen species (ROS), known as oxidants that can react with various cellular targets thereby causing cell damage or even cell death. On the other hand, recent work has demonstrated that H2O2 also functions as a signalling molecule controlling different essential processes in plants and mammals. Because of these opposing functions the cellular level Of H2O2 is likely to be subjected to tight regulation via processes involved in production, distribution and removal. Substantial progress has been made exploring the formation and scavenging of H2O2, whereas little is known about how this signal molecule is transported from its site of origin to the place of action or detoxification. From work in yeast and bacteria it is clear that the diffusion of H2O2 across membranes is limited. We have now obtained direct evidence that selected aquaporin homologues from plants and mammals have the capacity to channel H2O2 across membranes. The main focus of this review is (i) to summarize the most recent evidence for a signalling role of H2O2 in various pathways in plants and mammals and (ii) to discuss the relevance of specific transport Of H2O2. (c) 2006 Elsevier B.V. All rights reserved.