Potential contribution of insecticide exposure and development of obesity and type 2 diabetes.
Potential contribution of insecticide exposure and development of obesity and type 2 diabetes.
复制标题
接触杀虫剂以及肥胖和 2 型糖尿病发展的潜在影响。
DOI：
10.1016/j.fct.2017.05.003
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Park,Yeonhwa
中科院分区：
文献类型：
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作者：
Xiao,Xiao;Clark,JohnM;Park,Yeonhwa
杀虫剂的引入极大地提高了农业生产力和人类营养；然而，杀虫剂的广泛使用也引起了人们对其对健康影响的日益关注。癌症、神经退行性疾病、生殖功能障碍、出生缺陷、呼吸系统疾病、心血管疾病和衰老的增加与杀虫剂接触有关。与此同时，越来越多的证据表明，接触杀虫剂也会增加肥胖和2型糖尿病的风险。本文通过流行病学和啮齿动物研究综述了杀虫剂暴露与肥胖和2型糖尿病发病的关系，包括可能的机制。作为一个整体，证据表明，接触杀虫剂与肥胖和2型糖尿病风险增加有关。
The introduction of insecticides has greatly improved agricultural productivity and human nutrition; however, the wide use of insecticides has also sparked growing concern over their health impacts. Increased rate of cancers, neurodegenerative disorders, reproductive dysfunction, birth defects, respiratory diseases, cardiovascular diseases and aging have been linked with insecticide exposure. Meanwhile, a growing body of evidence is suggesting that exposure to insecticides can also potentiate the risk of obesity and type 2 diabetes. This review summarizes the relationship between insecticide exposure and development of obesity and type 2 diabetes using epidemiological and rodent animal studies, including potential mechanisms. The evidence as a whole suggests that exposure to insecticides is linked to increased risk of obesity and type 2 diabetes.