ENZYMIC ACTIVITIES AND SODIUM, POTASSIUM AND COPPER CONCENTRATIONS IN MOUSE BRAIN AND LIVER AFTER CUPRIZONE TREATMENT IN VIVO
ENZYMIC ACTIVITIES AND SODIUM, POTASSIUM AND COPPER CONCENTRATIONS IN MOUSE BRAIN AND LIVER AFTER CUPRIZONE TREATMENT IN VIVO
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DOI：
10.1111/j.1471-4159.1973.tb07569.x
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发表时间：
1973-11
影响因子：
4.7
通讯作者：
G. Venturini
中科院分区：
文献类型：
--
作者：
G. Venturini
摘要：给小鼠口服铜宗可诱导中枢神经系统的海绵状状态和肝脏中的巨大线粒体。脑、肝中单胺氧化酶、细胞色素氧化酶活性受到抑制，琥珀酸脱氢酶活性增加。钠浓度增加，钾浓度下降；脑干重和铜含量下降。用铜螯合铜宗治疗的动物没有表现出任何变化。
Abstract— The oral administration of cuprizone to mice induces status spongiosus in the CNS and giant mitochondria in the liver. The activities of monoamine oxidase and cytochrome oxidase in brain and liver are inhibited and succinate dehydrogenase activity is increased. There is an increase in sodium and decrease in potassium concentrations; brain dry weight and copper content are decreased. Animals treated with copper‐chelated cuprizone do not show any changes.