Abolishment of oral trypsin inhibitor stimulation of the rat exocrine pancreas after duodeno-jejunal resection.
Abolishment of oral trypsin inhibitor stimulation of the rat exocrine pancreas after duodeno-jejunal resection.
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十二指肠空肠切除术后口服胰蛋白酶抑制剂对大鼠外分泌胰腺的刺激的消除。
DOI：
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发表时间：
1976
影响因子：
1.9
通讯作者：
Ingemar Ihse
中科院分区：
文献类型：
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作者：
Ingemar Ihse
在未手术的大鼠和通过30%近端小肠切除术手术的大鼠中研究了长期口服胰蛋白酶抑制剂给药对外分泌胰腺的影响。进行了以下观察：在最后一次胰蛋白酶抑制剂摄入后18小时处死的未手术大鼠中，与对照组相比，胰腺湿重增加，胰腺蛋白增加，胰腺和肠胰蛋白酶（ogen）和胰腺淀粉酶增加。在手术大鼠中，以相同的方法处理和检查，未发现对胰腺外分泌的影响。这表明，胰蛋白酶抑制剂对手术大鼠胰腺外分泌的影响的消除反映了一种或多种肠道激素或因子的产生部位的去除。在最后一次摄入胰蛋白酶抑制剂后4小时检查的未手术大鼠中，发现胰腺胰蛋白酶原和淀粉酶减少以及肠淀粉酶增加，表明胰腺对腔内胰蛋白酶抑制剂的分泌反应;在这些大鼠中发现的肠胰蛋白酶低值可能反映了牛肺胰蛋白酶抑制剂对大鼠胰蛋白酶的抑制。
The effect of long-term oral trypsin inhibitor administration on the exocrine pancreas was studied in unoperated rats and in rats operated on by a 30% proximal small intestinal resection. The following observations were made: in unoperated rats sacrificed 18 hours after the last trypsin inhibitor ingestion there was an increase of the wet weight of pancreas, increase of the pancreatic protein, and an increase of pancreatic and intestinal trypsin(ogen) and of pancreatic amylase by comparison with the controls. In operated rats, treated and examined in an identical way, no influences on the exocrine pancreas were found. It is suggested that the abolishment of the trypsin inhibitor effects on the exocrine pancreas in operated rats reflects the removal of the site of production of one or more intestinal hormone(s) or factor(s) responsible for these effects. In unoperated rats examined 4 hours after the last trypsin inhibitor ingestion a reduction of the pancreatic trypsinogen and amylase and an increase of the intestinal amylase were found, indicating a secretory response of the pancreas to the intraluminal trypsin inhibitor; the low values of intestinal trypsin found in these rats probably reflect inhibition of rat trypsin by the bovine lung trypsin inhibitor.