Carotid intima-media thickness is increased and related to arterial stiffening in patients with beta-thalassaemia major
Carotid intima-media thickness is increased and related to arterial stiffening in patients with beta-thalassaemia major
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DOI：
10.1111/j.1365-2141.2006.06349.x
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发表时间：
2006-12-01
影响因子：
6.5
通讯作者：
Ha, S. Y.
中科院分区：
文献类型：
--
作者：
Cheung, Y. F.;Chow, P. C.;Ha, S. Y.
铁储备的增加与动脉粥样硬化的风险有关。对20例重型β-地中海贫血症患者的颈动脉内膜中层厚度(IMT)、僵硬指数、杨氏弹性模数(YEM)和增强指数进行了测定。与对照组相比，患者组的颈动脉内中膜厚度(P<；0.001)、肌张力指数(P=0.005)、僵硬指数(P=0.009)和增大指数(P=0.03)均显著高于对照组。患者IMT增加的优势比为39。颈动脉内膜厚度与YEM(P=0.036)、僵硬指数(P=0.036)和增强指数(P=0.006)相关。多变量分析确定患者状态(P<；0.001)是IMT的唯一重要决定因素。这些发现提示在重型β-地中海贫血症患者中存在过早动脉粥样硬化的可能性。
An increased iron store has been linked to the risk of atherosclerosis. The carotid intima-media thickness (IMT), stiffness index, Young's elastic modulus (YEM), and augmentation index were determined in 20 patients with beta-thalassaemia major. Compared with controls, patients had greater IMT (P < 0.001), YEM (P = 0.005), and stiffness (P = 0.009) and augmentation (P = 0.03) indices. The odds ratio for increased IMT in patients was 39. Carotid IMT correlated with YEM (P = 0.036), stiffness index (P = 0.036) and augmentation index (P = 0.006). Multivariate analysis identified patient status (P < 0.001) as the only significant determinant of IMT. These findings suggest the possibility of premature atherosclerosis in beta-thalassaemia major patients.