Pro-atrial natriuretic peptide and pro-vasopressin for predicting short-term and long-term survival in community-acquired pneumonia: results from the German Competence Network CAPNETZ
Pro-atrial natriuretic peptide and pro-vasopressin for predicting short-term and long-term survival in community-acquired pneumonia: results from the German Competence Network CAPNETZ
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DOI：
10.1136/thx.2009.121178
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发表时间：
2010-03-01
期刊：
影响因子：
10
通讯作者：
Welte, Tobias
中科院分区：
文献类型：
--
作者：
Krueger, Stefan;Ewig, Santiago;Welte, Tobias
背景社区获得性肺炎（CAP）是临床上最重要的感染，具有很高的长期死亡率。本研究的目的是评估生物标志物的短期和长期死亡率的预测在CAP.Methods的平均值+/- SD年龄60 +/- 18岁（45%的女性），共1740例患者的价值被证明CAP入组研究。入院时测定中段心房钠尿肽前体（MR-proANP）、C末端心房加压素前体（CT-proAVP）、降钙素原、C反应蛋白、白细胞计数（WBC）和CRB-65评分。结果根据CRB-65评分，CAP患者的MR-proANP和CT-proAVP水平随着CAP严重程度的增加而增加。在28和180天内死亡的患者中，中位MR-proANP（313.9 vs 80.0和277.8 vs 76.0 pmol/l，各p
Background Community-acquired pneumonia (CAP) is the most important clinical infection with a high long-term mortality rate. The aim of this study was to evaluate the value of biomarkers for the prediction of short-term and long-term mortality in CAP.Methods A total of 1740 patients of mean +/- SD age 60 +/- 18 years (45% female) with proven CAP were enrolled in the study. Mid-regional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-atrial vasopressin (CT-proAVP), procalcitonin, C-reactive protein, leucocyte count (WBC) and CRB-65 score were determined on admission. Patients were followed up for 180 days.Results MR-proANP and CT-proAVP levels increased with increasing severity of CAP, classified according to CRB-65 score. In patients who died within 28 and 180 days, median MR-proANP (313.9 vs 80.0 and 277.8 vs 76.0 pmol/l, each p