Monocyte recruitment and neointimal hyperplasia in rabbits - Coupled inhibitory effects of heparin
Monocyte recruitment and neointimal hyperplasia in rabbits - Coupled inhibitory effects of heparin
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DOI：
10.1161/01.atv.16.10.1312
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发表时间：
1996-10-01
影响因子：
8.7
通讯作者：
Edelman, ER
中科院分区：
文献类型：
--
作者：
Rogers, C;Welt, FGP;Edelman, ER
肝素的许多作用与其对凝血的作用无关，其中包括抑制血管平滑肌细胞的增殖和调节白细胞与血管的相互作用。在一种富含炎性细胞的血管损伤动物模型中，研究了这些影响之间的潜在联系：在兔髂动脉放置血管内金属支架。早期局灶性血栓刺激的单核细胞黏附在3d后最大，7d后单核细胞浸润性和内膜细胞增殖最大。各时间点组织单核细胞数决定细胞增殖(R(2)=0.92，P
Among the many effects of heparin independent of its effects on coagulation are inhibition of vascular smooth muscle cell proliferation and regulation of leukocyte-blood vessel interactions. The potential link between these effects was examined in an animal model of vascular injury rich in inflammatory cells: the placement of endovascular metal stents in rabbit iliac arteries. Monocyte adhesion stimulated by early focal thrombus was maximal after 3 days, with infiltrating monocytes and intimal cell proliferation maximal after 7 days. Tissue monocyte number dictated cell proliferation at each time point (R(2)=.92, P