THE EXPRESSION OF NON-CLUSTERED PROTOCADHERINS IN ADULT RAT HIPPOCAMPAL FORMATION AND THE CONNECTING BRAIN REGIONS
THE EXPRESSION OF NON-CLUSTERED PROTOCADHERINS IN ADULT RAT HIPPOCAMPAL FORMATION AND THE CONNECTING BRAIN REGIONS
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DOI：
10.1016/j.neuroscience.2010.05.027
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发表时间：
2010-09-29
期刊：
影响因子：
3.3
通讯作者：
Kim, H.
中科院分区：
文献类型：
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作者：
Kim, S. Y.;Mo, J. W.;Kim, H.
非成簇原钙粘素（PCDHs）是一类钙依赖性粘附分子，因其在发育过程中神经回路形成中的作用以及在自闭症和智力低下等神经系统疾病中的意义而引起人们的关注。在此之前，我们发现，一个子集的非集群PCDH表现出回路依赖的表达模式，在丘脑-皮质连接在出生后的早期大鼠大脑，但这种模式在成年后消失。在本研究中，我们发现非成簇的PCDHs在成年人海马和齿状回的亚区域中沿隔颞轴沿着表现出不同的表达模式，并具有地形偏好性。PCDH 1、PCDH 9、PCDH 10和PCDH 20的表达呈隔区偏好性，而PCDH 8、PCDH 11、PCDH 17和PCDH 19的表达呈时间偏好性，提示它们在海马内回路的形成/维持中发挥作用。PCDHs在与海马结构相连的内嗅皮层、外侧隔和基底外侧杏仁复合体等区域也表现出区域特异性表达。此外，三个PCDHs（PCDH 8，PCDH 19和PCDH 20）的表达水平的调节通过电休克刺激的大脑在成年海马和齿状回。这些结果表明，非成簇PCDH参与成人海马电路的维持和可塑性。(C)2010年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Non-clustered protocadherins (PCDHs) are calcium-dependent adhesion molecules which have attracted attention for their possible roles in the neuronal circuit formation during development and their implications in the neurological disorders such as autism and mental retardation. Previously, we found that a subset of the non-clustered PCDHs exhibited circuit-dependent expression patterns in thalamo-cortical connections in early postnatal rat brain, but such patterns disappeared in adulthood. In this study, we identified that the non-clustered PCDHs showed differential expression patterns along the septotemporal axis in the sub-regions of adult hippocampus and dentate gyrus with topographical preferences. The expressions of PCDH1, PCDH9, PCDH10 and PCDH20 showed septal preferences, whereas the expressions of PCDH8, PCDH11, PCDH17 and PCDH19 showed temporal preferences, suggesting that they play roles in the formation/maintenance of intrahippocampal circuits. PCDHs also exhibited the region-specific expression patterns in the areas connected to hippocampal formation such as entorhinal cortex, lateral septum, and basolateral amygdaloid complex. Furthermore, the expression levels of three PCDHs (PCDH8, PCDH19 and PCDH20) were regulated by the electroconvulsive shock stimulation of the brain in the adult hippocampus and dentate gyrus. These results suggest that non-clustered PCDHs are involved in the maintenance and plasticity of adult hippocampal circuitry. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.