The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma.
The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma.
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DOI：
10.1021/acs.biochem.5b00353
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发表时间：
2015-06-02
期刊：
影响因子：
2.9
通讯作者：
DeCoursey TE
中科院分区：
文献类型：
--
作者：
DeCoursey TE
描述了电压门控质子通道的主要特性，以及通道蛋白结构如何完成这些功能的已知内容。正如质子在离子中是独一无二的，质子通道在离子通道中也是独一无二的。它们的四个跨膜螺旋感应电压、pH梯度，并专门传导质子。选择性是通过h30 +独特的质子化Asp-Arg盐桥的能力来实现的。门控对pH梯度的病态敏感性确保了只有在酸挤压产生时通道才会打开，这对大多数生物功能至关重要。甲藻中有一个例外，H+通过HV1内流触发生物发光闪光。药物干预有望改善癌症、哮喘、缺血性中风脑损伤、阿尔茨海默病、自身免疫性疾病和许多其他疾病，等待未来的进展。
The main properties of voltage gated proton channels are described, along with what is known about how the channel protein structure accomplishes these functions. Just as protons are unique among ions, proton channels are unique among ion channels. Their four transmembrane helices sense voltage, the pH gradient, and conduct protons exclusively. Selectivity is achieved by the unique ability of H3O+ to protonate an Asp-Arg salt bridge. Pathognomonic sensitivity of gating to the pH gradient ensures channel opening only when acid extrusion will result, which is crucial to most biological functions. An exception occurs in dinoflagellates in which H+ influx through HV1 triggers the bioluminescent flash. Pharmacological interventions that promise to ameliorate cancer, asthma, brain damage in ischemic stroke, Alzheimer’s disease, autoimmune diseases, and numerous other conditions, await future progress.
Myxicola 中钠通道对碱金属阳离子的渗透性。
影响因子：
3.8
作者：
Ebert, G A;Goldman, L
通讯作者：
Goldman, L