Osteosarcoma arising in Paget's disease of the mandible
Osteosarcoma arising in Paget's disease of the mandible
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DOI：
10.1016/s1368-8375(02)00065-9
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发表时间：
2002-12-01
期刊：
影响因子：
4.8
通讯作者：
Finn, MD
中科院分区：
文献类型：
--
作者：
Cheng, YSL;Wright, JM;Finn, MD
虽然骨肉瘤是佩吉特骨疾病的常见并发症，但它很少发生在颌骨。我们提出了一个骨肉瘤发生在佩吉特病的下颌骨与独特的功能正常血清碱性磷酸酶水平，和组织学特征的毛细血管扩张的变化，骨肉瘤和骨牙骨质发育不良。16例骨肉瘤发生在佩吉特病的颌骨（OPJ）也进行了审查和比较发生在佩吉特病的骨肉瘤发生在整个骨骼（OPS）和骨肉瘤发生在颌骨（OJ）从头。女性更常参与OPJ，而男性在OPS和OJ中占主导地位。与OPS相比，OPJ也有明显更高的黑人比例。OPJ的预后很差，69%的患者在诊断后两年内死亡。早期识别、早期积极治疗对改善预后具有重要意义，因此受到重视. (C)2002爱思唯尔科技有限公司。保留所有权利。
Although osteosarcoma is a well-known complication of Paget's disease of bone, it uncommonly develops in the jaw bones. We present an osteosarcoma arising in Paget's disease of the mandible with unique features of a normal serum alkaline phosphatase level, and histologic features of telangiectatic change in the osteosarcoma and association with cemento-osseous dysplasia. Sixteen reported cases of osteosarcoma arising in Paget's disease of the jaw bones (OPJ) are also reviewed and compared to osteosarcoma arising in Paget's disease occurring in the entire skeleton (OPS) and osteosarcoma arising de novo in the jaw bones (OJ). Females are more commonly involved in OPJ in contrast to a male predominance in OPS and OJ. OPJ also has a distinctively higher percentage involving blacks compared to OPS. The prognosis of OPJ is poor, with 69% of patients dying within two years after diagnosis. Early recognition, early and aggressive treatment are important to improve the prognosis and are hence emphasized. (C) 2002 Elsevier Science Ltd. All rights reserved.