Lower mental health related quality of life precedes dementia diagnosis: findings from the EPIC-Norfolk prospective population-based study.
Lower mental health related quality of life precedes dementia diagnosis: findings from the EPIC-Norfolk prospective population-based study.
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DOI：
10.1007/s10654-023-01064-7
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发表时间：
2024-01
影响因子：
13.6
通讯作者：
Keevil, Victoria L.
中科院分区：
文献类型：
--
作者：
Chintapalli, Renuka;Myint, Phyo K.;Brayne, Carol;Hayat, Shabina;Keevil, Victoria L.
健康相关生活质量（HRQoL）较低在美国老年人中先于痴呆症。我们探讨了HRQoL和痴呆症在英国成年人在中年和晚年的前瞻性关联，当干预措施，以优化认知老化可能提供的好处。7，452名社区居民参与者（57%为女性;平均年龄69.3 ± 8.3岁）参加了欧洲癌症前瞻性调查-诺福克研究的第三次健康检查（3 HC），并使用简明健康调查量表36（SF-36）报告了他们的HRQoL。考克斯比例风险回归模型探讨了基线身体成分（PCS）和精神成分总结（MCS）评分以及8个SF-36子量表（身体功能、角色-身体、身体疼痛、一般健康、活力、社会功能、角色-情感、精神健康）的标准差差异与10年内痴呆事件之间的相关性。Logistic回归模型探讨了HRQoL和客观整体认知功能之间在3 HC的横截面关系（n = 4435;认知不良=最低表现十分位数）。考虑到社会人口统计学和合并症，按年龄组（50-69岁，≥ 70岁）对队列进行整体检查。较高的MCS评分与较低的痴呆发病率（风险比[HR] = 0.74，95% CI 0.68-0.81）和较低的认知能力差几率（比值比[OR] = 0.82，0.76-0.89）相关，不同年龄组的结果相似。较高的PCS评分与整个队列（HR = 0.93，0.84-1.04）或考虑年龄组的痴呆无关;仅与年轻参与者的认知能力差相关（OR = 0.81，0.72-0.92）。同样，较高的分数与精神，但不是身体，HRQoL和较低的痴呆发病率之间的关联进行了观察。在英国中老年人群中，较低的精神HRQoL先于痴呆诊断在线版本包含补充材料，可通过10.1007/s10654-023-01064-7获得。
Lower Health Related Quality of Life (HRQoL) precedes dementia in older adults in the USA. We explore prospective associations between HRQoL and dementia in British adults in mid and late-life, when interventions to optimise cognitive ageing may provide benefit. 7,452 community-dwelling participants (57% women; mean age 69.3 ± 8.3 years) attended the European Prospective Investigation of Cancer-Norfolk study’s third health check (3HC) and reported their HRQoL using Short-Form 36 (SF-36). Cox Proportional Hazard regression models explored associations between standard deviation differences in baseline Physical Component (PCS) and Mental Component Summary (MCS) scores, as well as eight SF-36 sub-scales (physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, mental health), and incident dementia over ten years. Logistic regression models explored cross-sectional relationships at the 3HC between HRQoL and objective global cognitive function (n = 4435; poor cognition = lowest performance decile). The cohort was examined as a whole and by age-group (50–69, ≥ 70), considering socio-demographics and co-morbidity. Higher MCS scores were associated with lower chance of incident dementia (Hazard Ratio [HR] = 0.74, 95% CI 0.68–0.81) and lower odds of poor cognition (Odds Ratio [OR] = 0.82, 0.76–0.89), with findings similar by age-group. Higher PCS scores were not associated with dementia in the whole cohort (HR = 0.93, 0.84–1.04) or considering age-groups; and were only associated with poor cognition in younger participants (OR = 0.81, 0.72–0.92). Similarly, associations between higher scores on subscales pertaining to mental, but not physical, HRQoL and lower dementia incidence were observed. Lower mental HRQoL precedes dementia diagnosis in middle-aged and older British adults. The online version contains supplementary material available at 10.1007/s10654-023-01064-7.
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较老的黑人和白人成年人的压力与认知功能的关联。
影响因子：
13.8
作者：
Kulshreshtha, Ambar;Alonso, Alvaro;McClure, Leslie A.;Hajjar, Ihab;Manly, Jennifer J.;Judd, Suzanne
通讯作者：
Judd, Suzanne
影响因子：
2.1
作者：
Ezzati, Ali;Zammit, Andrea R.;Lipton, Richard B.
通讯作者：
Lipton, Richard B.
DOI：
10.1136/bmj.k2927
发表时间：
2018-08-01
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Sabia S;Fayosse A;Dumurgier J;Dugravot A;Akbaraly T;Britton A;Kivimäki M;Singh-Manoux A
通讯作者：
Singh-Manoux A
影响因子：
9.9
作者：
Hall, C. B.;Lipton, R. B.;Verghese, J.
通讯作者：
Verghese, J.
影响因子：
15.8
作者：
Matthews, F;Brayne, C
通讯作者：
Brayne, C