THE EFFECT OF TOPICAL TRETINOIN ON DYSPLASTIC NEVI - A PRELIMINARY TRIAL
THE EFFECT OF TOPICAL TRETINOIN ON DYSPLASTIC NEVI - A PRELIMINARY TRIAL
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DOI：
10.1001/archderm.126.4.494
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发表时间：
1990-04-01
影响因子：
--
通讯作者：
JAFFE, P
中科院分区：
文献类型：
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作者：
EDWARDS, L;JAFFE, P
21例患者入组了一项随机、双盲研究，该研究检查了局部0.05%维甲酸（全反式维甲酸;维生素A酸; Retin-A）溶液对发育不良痣的影响。在组织学确诊三个代表性病变的发育不良痣后，患者将维甲酸或含有50%酒精的安慰剂应用于选定的发育不良痣，每天一次，在胶带封闭下，或每天两次，不封闭，持续4个月。立即治疗后的比较照片显示显着褪色或消除一些发育不良痣临床上，切除活检标本的组织学检查显示消失或恢复良性痣在许多治疗病变。用安慰剂治疗的发育不良痣没有临床或组织学变化。本研究显示局部应用维甲酸对某些发育不良痣有明确的生物学效应。
Twenty-one patients were enrolled in a randomized, double-blind study that examined the effects of topical 0.05% tretinoin (all-trans-retinoic acid; vitamin a acid; Retin-A) solution on dysplastic nevi. Following histologic confirmation of the diagnosis of dysplastic nevus in three representative lesions, patients applied either tretinoin or a placebo containing 50% alcohol to selected dysplastic nevi once a day under tape occlusion, or twice a day unoccluded, for 4 months. Immediate posttreatment comparative photographs showed marked fading or elimination of some dysplastic nevi clinically, and histologic examination of excisional biopsy specimens showed disappearance or reversion to benign nevi in many of the treated lesions. There were no clinical or histologic changes in those dysplastic nevi treated with placebo. This study shows a definite biological effect of topical tretinoin on some dysplastic nevi.