RELATIONSHIP BETWEEN DEPRESSION, CLINICAL AND BIOCHEMICAL PARAMETERS IN PATIENTS UNDERGOING HAEMODIALYSIS
RELATIONSHIP BETWEEN DEPRESSION, CLINICAL AND BIOCHEMICAL PARAMETERS IN PATIENTS UNDERGOING HAEMODIALYSIS
复制标题
DOI：
10.1111/j.1755-6686.2012.00259.x
复制
发表时间：
2012-06-01
影响因子：
1.9
通讯作者：
Alivanis, Polichronis
中科院分区：
文献类型：
--
作者：
Bornivelli, Christina;Aperis, Georgios;Alivanis, Polichronis
在本文中，我们调查了45例血液透析（HD）患者的抑郁发生率及其与临床、实验室参数和睡眠障碍的关系。他们被分成两组。A组（n = 29）无抑郁，而B组（n = 16）有临床评估的抑郁。受试者在社会经济、临床、实验室参数和睡眠障碍方面进行比较。各组在年龄、性别、家庭状况、教育、自尊、咖啡和酒精消费、精神病史、HD时间和实验室（血清尿素、肌酐、电解质、铁、白蛋白和脂质）参数方面相匹配。与A组相比，B组显示出显著较低的血红蛋白水平（分别为11.13 +/-1.69和12.23 +/-1.31 g/dl; p < 0.01）和较高的C-反应蛋白（CRP）水平（分别为1.82 +/-1.73和0.83 +/-0.6 mg/dl; p < 0.005）。此外，当汉密尔顿抑郁量表评分与血红蛋白（r =-0.30，p < 0.05）、CRP（r = 0.38，p < 0.001）和AIS评分（r = 0.54，p < 0.0001）相关时，观察到强相关性。总之，抑郁症似乎与高CRP、低血红蛋白水平和睡眠障碍有关。
In this paper, we investigated the incidence of depression and its relation to clinical, laboratory parameters and sleep disorders in 45 haemodialysis (HD) patients. They were divided into two groups. Group A (n = 29) had no depression, whereas Group B (n = 16) had clinically assessed depression. Subjects were compared in terms of socioeconomic, clinical, laboratory parameters and presence of sleep disorders. Groups were matched for age, sex, family status, education, self-esteem, coffee and alcohol consumption, psychiatric history, time on HD and laboratory (serum urea, creatinine, electrolytes, iron, albumin and lipids) parameters. Group B demonstrated significantly lower haemoglobin levels (11.13 +/- 1.69 and 12.23 +/- 1.31 g/dl, respectively; p < 0.01) and higher C- Reactive Protein (CRP) levels (1.82 +/- 1.73 and 0.83 +/- 0.6 mg/dl, respectively; p < 0.005) compared to Group A. Additionally, strong correlation was observed when Hamilton Depression Scale scores were related to haemoglobin (r = - 0.30, p < 0.05), CRP (r = 0.38, p < 0.001) and AIS scores (r = 0.54, p < 0.0001). In conclusion, depression seems to be related to high CRP, low haemoglobin levels and sleep disorders.