Rodent Models of Binge Eating: Are They Models of Addiction?
Rodent Models of Binge Eating: Are They Models of Addiction?
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DOI：
10.1093/ilar.53.1.23
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发表时间：
2012-01-01
期刊：
影响因子：
2.5
通讯作者：
Babbs, R. Keith
中科院分区：
文献类型：
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作者：
Corwin, Rebecca L. W.;Babbs, R. Keith
最近发展的啮齿动物暴饮暴食模型也是食物成瘾模型吗？有效的模型应该满足第四版和第五版《精神疾病诊断与统计手册》（DSM）中所描述的暴食和物质依赖的人类标准。同样，暴饮暴食动物的行为特征应该与药物成瘾动物模型的特征相同。我们评估和讨论了目前的啮齿动物暴食模型，它们对科学理解暴食的贡献，它们在DSM标准方面的有效性，以及它们与成瘾模型的重叠。所描述的模型表明，反复间歇性地食用大量高脂肪或含糖食物（暴饮暴食）与行为变化有关，类似于滥用药物所描述的行为变化。相比之下，对照组以非暴饮暴食的方式食用同样的食物，并没有表现出“成瘾”的行为特征。因此，高脂肪/含糖食物本身并不会让人上瘾。相反，它们的消费方式似乎是至关重要的。此外，虽然啮齿动物的暴饮暴食和药物自我给药模型有相似之处，但我们不支持将暴饮暴食相关的饮食障碍重新分类为物质使用障碍，因为人类的这种疾病存在差异。
Are recently developed rodent models of binge eating also models of food addiction? Valid models should meet human criteria for both bingeing and substance dependence as described in the 4th edition and proposed for the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). Similarly, behavioral profiles of bingeing animals should share characteristics with those of animal models of drug addiction. We evaluate and discuss current rodent models of bingeing, their contributions to scientific understanding of bingeing, their validity with respect to DSM criteria, and their overlap with models of addiction. The models described indicate that repeated intermittent bouts in which large quantities of fatty or sugary foods are consumed (binges) are associated with behavioral changes similar to those described for drugs of abuse. In contrast, control groups consuming the same foods in a nonbinge-type manner do not exhibit an "addiction-like" behavioral profile. Thus, fatty/sugary foods in and of themselves do not appear to have addictive qualities. Rather, the manner in which they are consumed appears to be critical. In addition, while rodent models of bingeing and drug self-administration share similarities, we do not support reclassifying the bingeing-related eating disorders as substance use disorders because of differences that distinguish such disorders in humans.