Loss of calbindin-D28K from aging human cholinergic basal forebrain:: Relation to plaques and tangles
Loss of calbindin-D28K from aging human cholinergic basal forebrain:: Relation to plaques and tangles
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DOI：
10.1093/jnen/62.6.605
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发表时间：
2003-06-01
影响因子：
3.2
通讯作者：
Bu, J
中科院分区：
文献类型：
--
作者：
Geula, C;Nagykery, N;Bu, J
本实验室的研究表明，在人的基底前脑胆碱能神经元(BFCN)中，钙结合蛋白Calbindin D-28K(CB)在正常衰老过程中发生了大量的特异性丢失。在目前的一系列实验中，我们确定了与年龄相关的CB丢失与正常老年人大脑中斑块和缠结的存在和密度之间的关系。在23例年龄从20岁到93岁的患者中，我们观察到BFCN区和大脑皮层的斑块和缠绕。65岁以上患者的基底前脑内可见斑块。基底前脑和皮质的斑块密度与BFCN的比例呈显著负相关，BFCN中含有CB免疫反应。然而，2例表现为BFCN中CB大量丢失的老年患者的大脑中没有任何斑块。早在26岁时，BFCN就观察到了缠结。只有内嗅皮层的缠结与BFCN中CB的丢失呈显著负相关。BFCN中CB的丢失以及斑块和缠结的形成很可能是一般年龄相关过程的一部分，这些过程是平行发生的，而不是因果关系的。
Reports from our laboratory have indicated a substantial and specific loss of the calcium binding protein calbindin D-28K (CB) from the human basal forebrain cholinergic neurons (BFCN) in the course of normal aging. In the present set of experiments we determined the relationship between the age-related loss of CB and the presence and density of plaques and tangles in the brains of normal elderly. In 23 cases ranging in age from 20 to 93 years of age we observed plaques and tangles in the BFCN region and the cerebral cortex in a subset of cases. Plaques were seen in the basal forebrain in very few cases above 65 years. Plaque density in the basal forebrain and cortex displayed a significant negative correlation with the proportion of the BFCN, which contained CB immunoreactivity. However, the brains of 2 elderly cases that displayed a substantial loss of CB from the BFCN did not contain any plaques. Tangles were observed in the BFCN as early as 26 years of age. Only tangles in the entorhinal cortex showed a significant negative correlation with the loss of CB from the BFCN. It is likely that loss of CB from the BFCN and formation of plaques and tangles are part of general age-related processes that occur in parallel rather than being causally related.