Crystal Structures of Nadifloxacin Anhydride and Its Hemihydrate

Crystal Structures of Nadifloxacin Anhydride and Its Hemihydrate
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无水那氟沙星及其半水合物的晶体结构

DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
K. Hashimoto
K. Hashimoto
中科院分区：
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文献类型：
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作者：
M. Kido;K. Hashimoto

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用X射线衍射法测定了那二沙星[9-氟-6，7-二氢-8-（4-羟基-1-哌啶基）-5-甲基-1-氧代-1H，5H-苯并[i，j]喹嗪-2-甲酸，OPC-7251]酐及其半水合物的晶体结构。在这两种晶体中，两个晶体学上独立的分子（A和B）包含在不对称单元中。分子A的两个分子和分子B的两个分子通过对称中心周围的氢键紧密结合。这两种晶体中的那地沙星分子的结构特征非常相似。
The crystal structures of nadifloxacin [9-fluoro-6, 7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H, 5H-benzo[i, j]quinolizine-2-carboxylic acid, OPC-7251]anhydride and its hemihydrate were determined by X-ray analysis. In both crystals, two crystallographically independent molecules (A and B) are contained in an asymmetric unit. Two of molecule A and two of molecule B are tightly bound by hydrogen bonds around a center of symmetry. The structural features of nadifloxacin molecules in the two crystals are very similar to each other.