Cytobiological consequences of calcium-signaling alterations induced by human viral proteins
Cytobiological consequences of calcium-signaling alterations induced by human viral proteins
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DOI：
10.1016/j.bbamcr.2006.09.025
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发表时间：
2006-11-01
影响因子：
5.1
通讯作者：
Paterlini-Brechot, Patrizia
中科院分区：
文献类型：
--
作者：
Chami, Mounia;Oules, Benedicte;Paterlini-Brechot, Patrizia
由于钙信号传导调节特定和基本的细胞过程，因此它是病毒蛋白的理想靶标，以便病毒控制细胞功能并有利于其持续存在、增殖和传播。对病毒蛋白对钙信号影响的报告进行的详细分析表明，与病毒相关的胞浆钙水平升高可以增加病毒蛋白表达（HIV-1、HSV-1/2）、病毒复制（HBx、肠道病毒2B、HTLV-1 p12(I)、HHV-8、EBV）、病毒成熟（轮状病毒）、病毒释放 （肠道病毒 2B）和细胞永生化（EBV）。有趣的是，病毒引起的胞浆钙水平降低被发现与免疫细胞功能的抑制有关（HIV-1 Tat、HHV-8 K 15、EBV LMP2A）。最后，多种病毒蛋白能够调节细胞内钙信号传导以控制细胞活力（HIV-1 Tat、HTLV-1 p13(II)、HCV core、HBx、肠道病毒 2B、HHV-8 K7）。这些数据指出钙信号传导是病毒感染的关键细胞靶标，应该刺激进一步研究探索新的钙相关治疗策略。 (c) 2006 Elsevier B.V. 保留所有权利。
Since calcium-signaling regulates specific and fundamental cellular processes, it represents the ideal target of viral proteins, in order for the virus to control cellular functions and favour its persistence, multiplication and spread. A detailed analysis of reports focused on the impact of viral proteins on calcium-signaling has shown that virus-related elevations of cytosolic calcium levels allow increased viral protein expression (HIV-1, HSV-1/2), viral replication (HBx, enterovirus 2B, HTLV-1 p12(I), HHV-8, EBV), viral maturation (rotavirus), viral release (enterovirus 2B) and cell immortalization (EBV). Interestingly, virus-induced decreased cytosolic calcium levels have been found to be associated with inhibition of immune cells functions (HIV-1 Tat, HHV-8 K 15, EBV LMP2A). Finally, several viral proteins are able to modulate intracellular calcium-signaling to control cell viability (HIV-1 Tat, HTLV-1 p13(II), HCV core, HBx, enterovirus 2B, HHV-8 K7). These data point out calcium-signaling as a key cellular target for viral infection and should stimulate further studies exploring new calcium-related therapeutic strategies. (c) 2006 Elsevier B.V. All rights reserved.