Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
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N-甲基-1-(4-甲氧基苯基)-2-氨基丙烷（对甲氧基甲基苯丙胺，PMMA）的神经毒性评估。
DOI：
10.1016/0006-8993(92)91298-s
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Ricaurte,GA
中科院分区：
文献类型：
--
作者：
Steele,TD;Katz,JL;Ricaurte,GA
这些研究评估了n -甲基-1-（4-甲氧基苯基）-2-氨基丙烷（对甲氧基甲基苯丙胺；PMMA）的神经毒性潜力，这是一种在非法毒品市场上出现的安非他明类似物。反复皮下注射PMMA导致脑区域5-羟色胺（5-HT）和5-羟基吲哚乙酸（5-HIAA）浓度的持续剂量相关降低，以及[3H]帕罗西汀标记的5-HT摄取位点的密度降低。PMMA与对甲氧基苯丙胺（PMA）和3,4-甲基-烯二氧基甲基苯丙胺（MDMA）的神经毒性电位的比较表明，同等剂量的PMMA和PMA （80 mg/kg）产生的5-羟色胺的消耗相当，但这些消耗不如低剂量的MDMA （20 mg/kg）所诱导的那样明显。纹状体DA在长期基础上没有受到本研究中评估的任何环取代安非他明的影响。这些数据表明，PMMA，像PMA和MDMA一样，对脑5-羟色胺神经元产生长期（可能是神经毒性的）影响，但PMMA作为5-羟色胺神经毒素的效力不如MDMA。此外，他们提出了对非法使用PMMA的担忧，因为人类可能比啮齿动物对PMMA和相关药物的5-HT神经毒性作用更敏感。
These studies assessed the neurotoxic potential ofN-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine; PMMA), an amphetamine analog that has surfaced in the illicit drug market. Repeated subcutaneous injections of PMMA caused lasting, dose-related reductions in regional brain concentrations of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), and in the density of [3H]paroxetine-labelled 5-HT uptake sites. Comparison of the neurotoxic potential of PMMA to that of para-methoxyamphetamine (PMA) and 3,4-methyl-enedioxymethamphetamine (MDMA) showed that equivalent doses of PMMA and PMA (80 mg/kg) produced comparable depletions of 5-HT, but that these depletions were not as pronounced as those induced by a lower dose of MDMA (20 mg/kg). Striatal DA was not affected on a long-term basis by any of the ring-substituted amphetamines evaluated in this study. These data suggest that PMMA, like PMA and MDMA, produces long-term (possibly neurotoxic) effects on brain serotonin neurons, but that PMMA is less potent than MDMA as a 5-HT neurotoxin. Further, they raise concern over the illicit use of PMMA since humans could be more sensitive than rodents to the 5-HT neurotoxic effects of PMMA and related drugs.