Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy.
Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy.
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DOI：
10.1117/1.nph.10.1.013508
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发表时间：
2023-01
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影响因子：
5.3
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中科院分区：
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这项工作的目标是表面血流动力学的光信号的污染，这是人类大脑的非侵入性光学测量的主要障碍之一。确定频域（FD）近红外光谱（NIRS）中双斜率（DS）测量的最佳源-探测器距离，并证明DS成像对深层组织（大脑）与浅表组织（头皮）的优先灵敏度。基于双层和均匀散射介质中扩散理论的理论研究（计算机模拟）。在视觉刺激和全身血压振荡期间人脑DS成像的体内演示。平均距离（DS所需的两个源-检测器距离之间）是深度灵敏度的关键因素。使用FD NIRS和平均距离31 mm对人类枕叶进行的体内成像表明：（1）FD相位与强度相比，以及DS与单距离（SD）相比，对视觉刺激的血流动力学反应更大;（2）FD相位和DS的血流动力学主要由血流驱动，SD强度的血流动力学主要由血容量驱动。采用FD NIRS的DS成像可以抑制浅表血流动力学的混杂作用，而不依赖于短源-探测器距离的数据。这种能力对于人类大脑的非侵入性光学测量具有重要意义。
This work targets the contamination of optical signals by superficial hemodynamics, which is one of the chief hurdles in non-invasive optical measurements of the human brain. To identify optimal source–detector distances for dual-slope (DS) measurements in frequency-domain (FD) near-infrared spectroscopy (NIRS) and demonstrate preferential sensitivity of DS imaging to deeper tissue (brain) versus superficial tissue (scalp). Theoretical studies (in-silico) based on diffusion theory in two-layered and in homogeneous scattering media. In-vivo demonstrations of DS imaging of the human brain during visual stimulation and during systemic blood pressure oscillations. The mean distance (between the two source–detector distances needed for DS) is the key factor for depth sensitivity. In-vivo imaging of the human occipital lobe with FD NIRS and a mean distance of 31 mm indicated: (1) greater hemodynamic response to visual stimulation from FD phase versus intensity, and from DS versus single-distance (SD); (2) hemodynamics from FD phase and DS mainly driven by blood flow, and hemodynamics from SD intensity mainly driven by blood volume. DS imaging with FD NIRS may suppress confounding contributions from superficial hemodynamics without relying on data at short source–detector distances. This capability can have significant implications for non-invasive optical measurements of the human brain.