THE REPLICATION OF DNA IN ESCHERICHIA-COLI
THE REPLICATION OF DNA IN ESCHERICHIA-COLI
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DOI：
10.1073/pnas.44.7.671
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发表时间：
1958-01-01
影响因子：
11.1
通讯作者：
STAHL, FW
中科院分区：
文献类型：
--
作者：
MESELSON, M;STAHL, FW
通过密度梯度离心，研究了均匀 N15 取代的指数生长的大肠杆菌群体转移至 N14 培养基后，N15 在细菌 DNA（脱氧核糖核酸）分子中的分布。 DNA 分子的氮原子均匀分布在两个物理上连续的亚基之间。复制后，每个子分子都会收到其中的 1 个。这些亚基通过多次重复得以保留。
The distribution of N15 among molecules of bacterial DNA (deoxyribonucleic acid) following the transfer to N14 medium of a uniformly N15-substituted exponentially growing population of E. coli was studied by means of density-gradient centrifugation. The nitrogen atoms of a DNA molecule are distributed equally between 2 physically continuous subunits. Following duplication, each daughter molecule receives 1 of these. The subunits are conserved through many duplications.