Inverse correlation between coronary and retinal blood flows in patients with normal coronary arteries and slow coronary blood flow
Inverse correlation between coronary and retinal blood flows in patients with normal coronary arteries and slow coronary blood flow
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DOI：
10.1016/j.atherosclerosis.2013.10.033
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发表时间：
2014-01-01
期刊：
影响因子：
5.3
通讯作者：
Finkelstein, Ariel
中科院分区：
文献类型：
--
作者：
Arbel, Yaron;Sternfeld, Amir;Finkelstein, Ariel
背景：冠状动脉造影正常时出现的“冠状动脉慢血流”（SCF）现象是由于微血管和内皮功能障碍所致。通过测量视网膜血流速度可以无创地评估微循环。本研究的目的是评估“视网膜功能成像仪”(RFI) 装置作为诊断冠状动脉血流缓慢患者的无创方法的功效。方法：在 28 名冠状动脉正常的连续患者中测量通过校正 TIMI 帧计数评估的冠状动脉血流速度和通过 RFI 评估的视网膜小动脉血流。将患者分为两组：缓慢冠状动脉血流（SCF）组和正常冠状动脉血流（NCF）组。结果：视网膜和冠状动脉血流之间存在负相关性，因此在SCF组中观察到较高的视网膜动脉血流速度（分别为3.8 +/- 1.1 mm/s vs. 2.9 +/- 0.61 mm/s，p = 0.022）。 RFI 使用 ROC 分析诊断 SCF 的灵敏度为 73%，特异性为 77%。此外，SCF 患者的血清 LDL 胆固醇值较高（NCF 为 104.7 +/- 18.93 mg/dl，NCF 为 81.55 +/- 14.62 mg/dl，p = 0.005）、葡萄糖（NCF 为 96.9 +/- 23.0 mg/dl，NCF 为 83.55 +/- 9.7 mg/dl，p = 0.024）。和更低 他汀类药物消耗的百分比（NCF 中为 40.0% 对比 76.9%，p = 0.049）。结论：冠状动脉血流缓慢可以使用视网膜功能成像仪进行非侵入性诊断。冠状动脉正常、冠状动脉血流缓慢的患者，视网膜小动脉血流量较高。 SCF 的早期无创诊断可能有助于发现冠状动脉粥样硬化风险较高的个体，并为他们提供早期预防措施。 (C) 2013 Elsevier Ireland Ltd. 保留所有权利。
Background: The "Slow Coronary Flow" (SCF) phenomenon in the presence of angiographically normal coronaries is attributed to microvascular and endothelial dysfunction. The microcirculation can be non-invasively assessed by measuring retinal blood flow velocity. The aim of the present study was to evaluate the efficacy of the "Retinal Functional Imager" (RFI) device as a noninvasive method of diagnosing patients with slow coronary flow.Methods: Coronary blood flow velocity assessed by corrected TIMI Frame Count and retinal arterioles blood flow assessed by RFI were measured in 28 consecutive patients with normal coronary arteries. The patients were divided into 2 groups: a slow coronary flow (SCF) and a normal coronary flow (NCF) groups.Results: Inverse correlation was found between retinal and coronary blood flows so that higher retinal arterial flow velocity was observed in the SCF group (3.8 +/- 1.1 mm/s vs. 2.9 +/- 0.61 mm/s, respectively, p = 0.022). RFI provided 73% sensitivity and 77% specificity for diagnosing SCF using ROC analysis. Additionally, patients with SCF had higher values of serum LDL cholesterol (104.7 +/- 18.93 mg/dl vs. 81.55 +/- 14.62 mg/dl in NCF, p = 0.005), Glucose (96.9 +/- 23.0 mg/dl vs. 83.55 +/- 9.7 mg/dl in NCF, p = 0.024), and lower percentage of statin consumption (40.0% vs. 76.9% in NCF, p = 0.049).Conclusions: Slow coronary blood flow can be non-invasively diagnosed with Retinal Functional Imager. Patients with normal coronary arteries and slow coronary blood flow have high retinal arteriolar blood flow. Early non-invasive diagnosis of SCF might help detect individuals who are at higher risk to develop coronary atherosclerosis, and to provide them with early preventive measures. (C) 2013 Elsevier Ireland Ltd. All rights reserved.