A comparison of four particulate bone derivatives.
A comparison of four particulate bone derivatives.
复制标题
四种颗粒骨衍生物的比较。
DOI：
10.1097/00003086-199106000-00041
复制
发表时间：
1991
影响因子：
4.2
通讯作者：
D. E. Bach
中科院分区：
文献类型：
--
作者：
J. Hollinger;D. Mark;P. Goco;N. Quigley;R. W. Desverreaux;D. E. Bach
制备了四种颗粒骨基质衍生物的样品，并将其植入Long-Evans大鼠标准的临界大小的颅骨缺损处。脱钙骨基质(DBM)、骨再生基质以及软骨内(EAAA)和膜内(IAAA)来源的两种颗粒化学灭菌、去抗原、自溶的同种异体骨(AAA)将在原位颅骨缺损中获得骨再生。这四种制剂在8 mm的原位颅骨创面上进行了测试，以比较移植后28天形成的新骨的数量。定量计算机成像测量新生骨小梁(钙化+类骨质)的X线灰度级和骨体积。所有实验性骨基质衍生物产生的骨体积都比未经处理的对照创面多。IAAA再生的骨体积明显小于EAAA和DBM再生的骨。
Samples of four types of particulate bone matrix derivatives were prepared and surgically inserted into standardized critical-sized defects in calvariae of Long-Evans rats. Implantation of demineralized bone matrix (DBM), bone regenerative matrix, and two types of particulate chemosterilized, antigen-extracted, autolyzed, allogeneic (AAA) bone from endochondral (eAAA) and intramembranous (iAAA) sources will result in the regeneration of bone in orthotopic skull defects. The four preparations were tested in orthotopic, 8-mm calvarial wounds to compare the quantity of new bone that formed 28 days postimplantation. Quantitative computer imaging was used to measure roentgenographic gray levels and bone volume of new trabeculae (calcified plus osteoid). All experimental bone matrix derivatives produced more bone volume than the nontreated control wounds. Bone volume regenerated from iAAA was significantly less than eAAA and DBM-regenerated bone.