In search of an auditory engram
In search of an auditory engram
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DOI：
10.1073/pnas.0503998102
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发表时间：
2005-06-28
影响因子：
11.1
通讯作者：
Saunders, RC
中科院分区：
文献类型：
--
作者：
Fritz, J;Mishkin, M;Saunders, RC
术前接受旨在评估听觉识别记忆的任务训练的猴子在去除头侧颞上回或内侧颞叶后受到损害，但未受到鼻皮质损伤的影响。行为分析表明，出现这种结果是因为猴子没有或不能使用长期听觉识别，而是依赖于短期工作记忆，而短期工作记忆不受鼻部病变的影响。研究结果表明，猴子可能无法将听觉刺激的表征长期存储，因此质疑猴子在听觉中的大脑记忆机制是否与其他感觉方式有本质上的不同。此外，它提出了一种可能性，即语言是人类独有的，不仅因为它依赖于言语，而且因为它需要长期的听觉记忆。
Monkeys trained preoperatively on a task designed to assess auditory recognition memory were impaired after removal of either the rostral superior temporal gyrus or the medial temporal lobe but were unaffected by lesions of the rhinal cortex. Behavioral analysis indicated that this result occurred because the monkeys did not or could not use long-term auditory recognition, and so depended instead on short-term working memory, which is unaffected by rhinal lesions. The findings suggest that monkeys may be unable to place representations of auditory stimuli into a long-term store and thus question whether the monkey's cerebral memory mechanisms in audition are intrinsically different from those in other sensory modalities. Furthermore, it raises the possibility that language is unique to humans not only because it depends on speech but also because it requires long-term auditory memory.