Molecular architecture of postsynaptic Interactomes.
Molecular architecture of postsynaptic Interactomes.
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DOI：
10.1016/j.cellsig.2020.109782
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发表时间：
2020-12
影响因子：
4.8
通讯作者：
Coba MP
中科院分区：
文献类型：
--
作者：
Wilkinson B;Coba MP
突触后密度（PSD）在突触信号机制的组织中起着重要作用。它包含一组核心支架蛋白，为PSD蛋白-蛋白相互作用网络（PINs）提供骨架。这些核心支架蛋白可被视为按蛋白家族分类的三个主要层，DLG蛋白位于顶部，SHANKs沿着底部，DLGAPs连接这两层。利用酵母双杂交的早期研究能够鉴定多层支架蛋白中的直接蛋白相互作用（PPIs）。最近，质谱法已经允许在PSD内的整个相互作用组的表征。这一知识的扩展进一步巩固了核心支架家族成员在突触pin中的中心地位，并为其在神经元发育和突触功能中的作用提供了背景。在这里，我们讨论了PSD的支架机制，它们在突触pin组织中的基本功能，以及它们与复杂脑疾病中受损的神经元过程的关系。
The postsynaptic density (PSD) plays an essential role in the organization of the synaptic signaling machinery. It contains a set of core scaffolding proteins that provide the backbone to PSD protein-protein interaction networks (PINs). These core scaffolding proteins can be seen as three principal layers classified by protein family, with DLG proteins being at the top, SHANKs along the bottom, and DLGAPs connecting the two layers. Early studies utilizing yeast two hybrid enabled the identification of direct protein-protein interactions (PPIs) within the multiple layers of scaffolding proteins. More recently, mass-spectrometry has allowed the characterization of whole interactomes within the PSD. This expansion of knowledge has further solidified the centrality of core scaffolding family members within synaptic PINs and provided context for their role in neuronal development and synaptic function. Here, we discuss the scaffolding machinery of the PSD, their essential functions in the organization of synaptic PINs, along with their relationship to neuronal processes found to be impaired in complex brain disorders.
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影响因子：
30.8
作者：
Durand, Christelle M.;Betancur, Catalina;Bourgeron, Thomas
通讯作者：
Bourgeron, Thomas
DOI：
10.1523/jneurosci.4457-06.2007
发表时间：
2007-03-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cuthbert PC;Stanford LE;Coba MP;Ainge JA;Fink AE;Opazo P;Delgado JY;Komiyama NH;O'Dell TJ;Grant SG
通讯作者：
Grant SG
影响因子：
4.8
作者：
Cabello, Nuria;Remelli, Rosaria;Ciruela, Francisco
通讯作者：
Ciruela, Francisco
影响因子：
4.7
作者：
Boeckers, TM;Liedtke, T;Gundelfinger, ED
通讯作者：
Gundelfinger, ED
影响因子：
16.2
作者：
Elias, Guillermo M.;Funke, Lars;Nicoll, Roger A.
通讯作者：
Nicoll, Roger A.