CLINICAL USE OF RESERPINE IN PSYCHIATRY - COMPARISON WITH CHLORPROMAZINE
CLINICAL USE OF RESERPINE IN PSYCHIATRY - COMPARISON WITH CHLORPROMAZINE
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DOI：
10.1111/j.1749-6632.1955.tb42463.x
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发表时间：
1955-01-01
期刊：
影响因子：
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通讯作者：
STOLL, WA
中科院分区：
文献类型：
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作者：
BLEULER, M;STOLL, WA
利血平和氯丙嗪（3-氯-10-（3“二甲基氨基丙基）-吩噻嗪）治疗在严重的精神病医院患者中产生类似的效果。他们放松和抚慰病人，使他们更好地平衡，并允许他们从不健康中恢复。利血平和氯丙嗪与长期麻醉、胰岛素或电击疗法一样有效，危险性更小。利血平优于氯丙嗪的优点是肌肉注射后引起的疼痛性浸润较少，而且对肝脏的损害可能较小。氯丙嗪的优点是它不太容易导致帕金森症状。在精神分裂症的治疗中，利血平和氯丙嗪在某些领域都可以达到与较早的物理治疗相同的效果，但危险性较小：例如，在治疗急性期、短暂的精神分裂症或精神分裂症样精神病方面，以及在治疗严重的慢性精神分裂症方面。然而，可治愈的精神分裂症患者的治愈趋势缓慢，平均而言，胰岛素治疗比氯丙嗪或利血平更有利。利血平和氯丙嗪也适用于躁狂抑郁性精神病、器质性和心因性兴奋状态，可能也适用于舞蹈病。
Reserpine and chlorpromazine (3 chloro-10-(3''dimethyl-aminopropyl)-phenothiazine) treatments produce similar effects in severe psychiatric hospital patients. They relax and soothe patients, make them better-balanced, and allow them to recover from ill health. Reserpine and chlorpromazine are as efficient and less dangerous than extended narcosis, insulin, or electroshock therapies. Advantages that reserpine has over chlorpromazine are that it causes less painful infiltrates after intramuscular injections, and that it probably causes less damage to the liver. Chlorpromazine has the advantage that it less frequently leads to Parkinson symptoms. There are areas in the treatment of schizophrenia in which both reserpine and chlorpromazine can achieve, with less danger, the same results as the older physical treatments: in the treatment of preacute, short-lasting schizophrenic or schizophrenic-like psychosis, for example, and in treating severe chronic schizophrenics. Curable schizophrenics having a slow tendency to cure, however, appear, on the average, to react more favorably to insulin therapy than to chlorpromazine or reserpine. Reserpine and chlorpromazine are also indicated in cases of manic-depressive psychosis, in organic and psycho-genic states of excitation and, probably, in choreic cases as well.