Pharmaceuticals and personal care products (PPCPs) in surface water and fish from three Asian countries: Species-specific bioaccumulation and potential ecological risks
Pharmaceuticals and personal care products (PPCPs) in surface water and fish from three Asian countries: Species-specific bioaccumulation and potential ecological risks
复制标题
三个亚洲国家地表水和鱼类中的药品和个人护理产品 (PPCP)：物种特异性生物累积和潜在生态风险
DOI：
10.1016/j.scitotenv.2022.161258
复制
发表时间：
2023
影响因子：
9.8
通讯作者：
Nom
中科院分区：
文献类型：
--
作者：
Nozaki Kazusa;Tanoue Rumi;Kunisue Tatsuya;Tue Nguyen Minh;Fujii Sadahiko;Sudo Nao;Isobe Tomohiko;Nakayama Kei;Sudaryanto Agus;Subramanian Annamalai;Bulbule Keshav A.;Parthasarathy Peethambaram;Tuyen Le Huu;Viet Pham Hung;Kondo Masakazu;Tanabe Shinsuke;Nom
在亚洲发展中国家，不发达和效率低下的下水道系统正在造成许多污染物，特别是药品和个人护理产品(PPCP)对地表水的污染。因此，需要评估淡水动物的风险。本研究的目的是：i)阐明污染状况；ii)评估生物累积；iii)评估三个亚洲国家地表水和淡水鱼中PPCP残留的潜在风险。我们测量了几种鱼类的血浆以及从印度(金奈和班加卢市)、印度尼西亚(雅加达和坦格朗)和越南(河内和华平)采集的环境水样中的43个PPCP。此外，对于可电离和易代谢的PPCPs，评估了仅基于化学物质的亲脂性的现有鱼类血-水分配模型的有效性。根据鱼和水中PPCP浓度计算的生物积累因子(BFA测量)与由它们的pH依赖的辛醇-水分配系数预测的生物浓缩因子(BCF预测值)相比，58-91%的被检测化合物的预测值接近(在一个数量级内)。然而，在罗非鱼中发现的抗组胺药物扑尔敏的血浆BAF值比BCF值高出110倍，而在其他鱼类中则没有。该化合物在三个鱼种(罗非鱼和鲤鱼)中的血浆BAF值有显著差异，可能是由于不同物种在毒物动力学上的差异(例如血浆蛋白结合和肝脏代谢)。根据测定的鱼血浆中PPCP浓度进行的潜在风险评估结果表明，扑尔敏、三氯生、氟哌啶醇、三氯卡班、双氯芬酸和苯海拉明对野生鱼具有潜在的不利影响。根据地表水中测量的PPCP浓度进行的潜在风险评估结果表明，卡马西平、磺胺甲恶唑、红霉素和三氯生对亚洲淡水生态系统具有很高的生态风险。
In Asian developing countries, undeveloped and ineffective sewer systems are causing surface water pollution by a lot of contaminants, especially pharmaceuticals and personal care products (PPCPs). Therefore, the risks for freshwater fauna need to be assessed. The present study aimed at: i) elucidating the contamination status; ii) evaluating the bioaccumulation; and iii) assessing the potential risks of PPCP residues in surface water and freshwater fish from three Asian countries. We measured 43 PPCPs in the plasma of several fish species as well as ambient water samples collected from India (Chennai and Bengaluru), Indonesia (Jakarta and Tangerang), and Vietnam (Hanoi and Hoa Binh). In addition, the validity of the existing fish blood–water partitioning model based solely on the lipophilicity of chemicals is assessed for ionizable and readily metabolizable PPCPs. When comparing bioaccumulation factors calculated from the PPCP concentrations measured in the fish and water (BAFmeasured) with bioconcentration factors predicted from their pH-dependent octanol–water partition coefficient (BCFpredicted), close values (within an order of magnitude) were observed for 58–91 % of the detected compounds. Nevertheless, up to 110 times higher plasma BAFmeasuredthan the BCFpredictedwere found for the antihistamine chlorpheniramine in tilapia but not in other fish species. The plasma BAFmeasuredvalues of the compound were significantly different in the three fish species (tilapia > carp > catfish), possibly due to species-specific differences in toxicokinetics (e.g., plasma protein binding and hepatic metabolism). Results of potential risk evaluation based on the PPCP concentrations measured in the fish plasma suggested that chlorpheniramine, triclosan, haloperidol, triclocarban, diclofenac, and diphenhydramine can pose potential adverse effects on wild fish. Results of potential risk evaluation based on the PPCP concentrations measured in the surface water indicated high ecological risks of carbamazepine, sulfamethoxazole, erythromycin, and triclosan on Asian freshwater ecosystems.