Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
Global cerebral oxidative metabolism during hypercapnia and hypocapnia in humans: implications for BOLD fMRI
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DOI：
10.1038/jcbfm.2010.42
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发表时间：
2010-06-01
影响因子：
6.3
通讯作者：
Pike, G. Bruce
中科院分区：
文献类型：
--
作者：
Chen, J. Jean;Pike, G. Bruce
二氧化碳(CO2)对大脑新陈代谢的影响是功能成像领域的研究热点。特别是，轻到中度的高碳酸血症通常用于基于校准的血氧水平依赖(BOLD)-功能磁共振成像(FMRI)的大脑氧化代谢变化(Delta CMRO2)的量化，并依赖于在二氧化碳挑战期间CMRO2稳定的假设。然而，这一假设受到了某些动物研究的挑战，需要在人类身上和在习惯于功能磁共振的条件下进行验证。我们首次报道了全球Delta CMRO2在人类分级高碳酸血症和低碳酸血症期间的无创测量结果。我们使用计算机化的呼气末二氧化碳调制来最大限度地减少氧分压的不受欢迎的同时变化，我们的发现表明，在呼气末二氧化碳变化的水平上，预计全球CMRO2不会发生重大变化，这是校准BOLD的惯常水平。《脑血流与代谢杂志》(2010)30期，1094-1099期；doi：10.1038/jcbfm.2010.42；2010年4月7日在线出版
The effect of carbon dioxide (CO2) on cerebral metabolism is of tremendous interest to functional imaging. In particular, mild-to-moderate hypercapnia is routinely used in calibrated blood oxygen-level dependent (BOLD)-functional magnetic resonance imaging (fMRI)-based quantification of cerebral oxidative metabolism changes (Delta CMRO2), and relies on the assumption of a stable CMRO2 during CO2 challenges. However, this assumption has been challenged by certain animal studies, necessitating its verification in humans and under conditions customary to fMRI. We report, for the first time, on global Delta CMRO2 measurements made noninvasively in humans during graded hypercapnia and hypocapnia. We used computerized end-tidal CO2 modulation to minimize undesired concurrent changes in oxygen pressure, and our findings suggest that no significant change in global CMRO2 is expected at the levels of end-tidal CO2 changes customary to calibrated BOLD. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1094-1099; doi: 10.1038/jcbfm.2010.42; published online 7 April 2010