Molecular biology and genetics of allergy and asthma
Molecular biology and genetics of allergy and asthma
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DOI：
10.1136/adc.78.5.488
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发表时间：
1998-05-01
影响因子：
5.2
通讯作者：
Morrison, JFJ
中科院分区：
文献类型：
--
作者：
Anderson, GG;Morrison, JFJ
在过去的几年里，在细胞和亚细胞水平上对变态反应的发病机制的理解已经取得了相当大的进展。特别是，细胞生物学和DNA技术的进步已经揭示了细胞相互作用，这些相互作用在协调过敏反应的炎症中至关重要。虽然现在已经在过敏性炎症的细胞机制方面建立了很多，但为什么有些人患有这种疾病而另一些人没有的基本问题才开始由分子遗传学来回答，这涉及到几个易患过敏症的基因的遗传。
In the past few years considerable progress has been made in understanding the pathogenesis of allergy at the cellular and subcellular level. In particular, advances in cell biology and DNA technology have shed light on the cell interactions that are pivotal in orchestrating the inflammation underlying allergy. Although much has now been established in the cellular mechanism of allergic inflammation, the fundamental question of why some people suVer from the disease and others do not has only begun to be answered by molecular genetics, which has implicated the inheritance of several genes that predispose to the development of allergy.