GROWTH OF ADIPOSE-TISSUE IN CHILDREN AND ADOLESCENTS - CROSS-SECTIONAL AND LONGITUDINAL-STUDIES OF ADIPOSE CELL NUMBER AND SIZE
GROWTH OF ADIPOSE-TISSUE IN CHILDREN AND ADOLESCENTS - CROSS-SECTIONAL AND LONGITUDINAL-STUDIES OF ADIPOSE CELL NUMBER AND SIZE
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DOI：
10.1172/jci109295
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发表时间：
1979-01-01
影响因子：
15.9
通讯作者：
KATZ, DP
中科院分区：
文献类型：
--
作者：
KNITTLE, JL;TIMMERS, K;KATZ, DP
对288名年龄从4个月到10个月不等的受试者进行了脂肪细胞大小和数量的测定。19岁该研究在110名肥胖和178名非肥胖受试者中进行。还对132例受试者进行了纵向随访研究（4年）。在非肥胖儿童中，细胞数量和大小对脂肪库生长的贡献明显随年龄而变化。在1岁后不久的肥胖儿童中观察到这种正常发育的偏离。到11岁时，肥胖儿童的平均细胞数超过了非肥胖成人的平均细胞数。肥胖受试者的细胞数量和大小均显示出更快和更早的升高，并在整个研究期间保持不变。与非肥胖儿童相比，肥胖儿童在脂肪组织发育方面表现出数量和质量上的差异。在儿童中遇到的脂肪组织细胞发育的速率和类型可能在肥胖受试者中发现的扩大的脂肪库的发育中起作用。
Adipocyte size and number were determined in 288 subjects ranging in age from 4 mo.-19 yr. The study was performed in 110 obese and 178 nonobese subjects. Longitudinal, follow-up studies (4 yr) were also performed in 132 subjects. The contribution of cell number and size to the growth of the fat depot in nonobese children apparently varies with age. Deviations from this normal development were observed in obese children shortly after 1 yr of age. By 11 yr of age obese children exceeded the mean cell number found in nonobese adults. Obese subjects displayed more rapid and earlier elevations in both cell number and size, which were maintained throughout the study. Obese children display quantitative and qualitative differences in fat tissue development when compared to nonobese children. The rate and type of adipose tissue cellular development one encounters in children may play a role in the development of the enlarged fat depots found in obese subjects.