EFFECTS OF ENDOTHELIN ON THE CORONARY VASCULAR BED IN OPEN-CHEST DOGS
EFFECTS OF ENDOTHELIN ON THE CORONARY VASCULAR BED IN OPEN-CHEST DOGS
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DOI：
10.1161/01.res.65.5.1193
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发表时间：
1989-11-01
影响因子：
20.1
通讯作者：
CLOZEL, M
中科院分区：
文献类型：
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作者：
CLOZEL, JP;CLOZEL, M
本研究的目的是评价内皮素对冠状动脉血管床的影响，内皮素是一种新发现的由内皮细胞分泌的非常有效的血管收缩剂。为此，在开胸麻醉的犬中测试冠状动脉内注射内皮素的效果，其中回旋冠状动脉插管并在100 mm Hg的恒定压力下灌注。测量了回旋支血流量、冠状动脉血流量的透壁分布（放射性微球）、回旋支冠状动脉直径（压电晶体）和回旋支管腔表面积。内皮素在1 μ g和3 μ g的剂量下分别使冠状动脉血流量减少30%和61%。10 μ g的剂量是致命的。心外膜下冠状动脉血流量的减少比心内膜下大，这解释了心内膜-心外膜血流量比从1.27 ± 0.01增加。0.05至1.98 ±。0.23（p
The goal of the present study was to evaluate the effects of endothelin, a newly discovered very potent vasoconstrictor secreted by endothelial cells, on the coronary vascular bed. For this purpose, the effects of endothelin injected intracoronarily were tested in open-chest anesthetized dogs with the circumflex coronary artery cannulated and perfused at a constant pressure of 100 mm Hg. Circumflex blood flow, transmural distribution of coronary blood flow (radioactive microspheres), circumflex coronary artery diameter (piezoelectric crystals), and circumflex luminal surface area were measured. Endothelin decreased coronary blood flow by 30% and 61% with doses of 1 and 3 .mu.g, respectively. A dose of 10 .mu.g was lethal. The decrease of coronary blood flow was larger in the subepicardium than in the subendocardium, which explains that the endocardial-epicardial blood flow ratio increased from 1.27.+-.0.05 to 1.98.+-.0.23 (p