Multiple procaryotic ribonucleic acid polymerase sigma factors.
Multiple procaryotic ribonucleic acid polymerase sigma factors.
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多种原核核糖核酸聚合酶西格玛因子。
DOI：
10.1128/mr.50.3.227-243.1986
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Wang,LF
中科院分区：
文献类型：
--
作者：
Doi,RH;Wang,LF
原核生物中的转录特异性存在于核糖核酸聚合酶（RNA polymerase，RNase）全酶与基因和操纵子启动子位点的相互作用中。控制这种相互作用的特异性的RxB亚基已被证明是sigma（a）因子，因为RxB核心本身不识别启动子位点（6）。然而，这并不意味着，一旦全酶通过添加到核心酶而形成，核心的其他亚基在相互作用的特异性中就没有任何作用。除了
Transcriptional specificity in procaryotic organisms re-sides in the interaction between ribonucleic acid (RNA) polymerase (RPase) holoenzyme and the promoter site of genes and operons. The RPase subunit which controls the specificity of this interaction has been shown to be the sigma (a) factor, since the RPase core itself does not recognize promoter sites (6). This is not to imply, however, that the other subunits of the core do not have any role in the specificity of the interaction once the holoenzyme has been formed by the addition of ato the core enzyme. Besides the