Kernel Mixed Model for Transcriptome Association Study.
Kernel Mixed Model for Transcriptome Association Study.
复制标题
用于转录组关联研究的内核混合模型。
DOI:
10.1089/cmb.2022.0280
复制
发表时间:
2022
期刊:
影响因子:
--
通讯作者:
Wu,Wei
中科院分区:
文献类型:
--
作者:
Wang,Haohan;Lopez,Oscar;Xing,EricP;Wu,Wei
We introduce the python software package Kernel Mixed Model (KMM), which allows users to incorporate the network structure into transcriptome-wide association studies (TWASs). Our software is based on the association algorithm KMM, which is a method that enables the incorporation of the network structure as the kernels of the linear mixed model for TWAS. The implementation of the algorithm aims to offer users simple access to the algorithm through a one-line command. Furthermore, to improve the computing efficiency in case when the interaction network is sparse, we also provide the flexibility of computing with the sparse counterpart of the matrices offered in Python, which reduces both the computation operations and the memory required.
登录
查看更多内容
DOI:
--
发表时间:
1986
期刊:
Biochemical and Biophysical Research Communications - BBRC
影响因子:
--
作者:
G. M. Sontheimer;W. Kuhn;H. Kalbitzer
通讯作者:
H. Kalbitzer
DOI:
--
发表时间:
1985
期刊:
影响因子:
--
作者:
R. V. Prigodich;P. Haake
通讯作者:
P. Haake
影响因子:
2.9
作者:
N. J. Birch;I. Goulding
通讯作者:
I. Goulding
影响因子:
4.8
作者:
R. Gupta;J. Benovic;Z. B. Rose
通讯作者:
Z. B. Rose
影响因子:
15
作者:
A. C. Plaush;R. Sharp
通讯作者:
R. Sharp