Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy.
Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy.
复制标题
与 HIV-1 感染和联合抗逆转录病毒治疗相关的脂肪重新分布综合征。
作者：
P. Domingo;V. Estrada;J. López;Francesc Villaroya;E. Martinez
在采用高效抗逆转录病毒疗法15年多之后，HIV/HAART相关脂肪营养不良综合征仍然影响着抗逆转录病毒疗法无可争议的疗效。与该并发症相关的几个问题（患病率、诊断、发病机制、预防或临床管理）尚未完全阐明。然而，在过去几年中，在阐明其中一些基本方面方面取得了重大进展。这包括更好地了解HIV/HAART相关脂肪营养不良综合征的致病机制，如遗传宿主决定因素，HIV感染本身的影响，以及抗逆转录病毒治疗的作用。在治疗方面，我们了解到某些药物特别容易引起HIV/HAART相关的脂肪营养不良综合征（即胸苷类似物）。治疗这种疾病的药物干预措施大多取得了令人失望的结果，唯一能为HIV/HAART相关脂肪营养不良综合征患者提供立即美学改善的干预措施是整形手术。即使在最有利的条件下（理想的宿主遗传组成，以及及时开始使用毒性较小的药物进行HIV治疗），目前的数据显示，HIV/HAART相关的脂肪代谢障碍综合征是HIV感染和/或抗逆转录病毒治疗的并发症，我们无法避免。在长期接受抗逆转录病毒治疗的HIV-1感染患者的背景下，脂肪毒性仍然是彩虹的黑暗面。
More than 15 years after the introduction of highly active antiretroviral therapy, HIV/HAART-associated lipodystrophy syndrome still shadows the indisputable efficacy of antiretroviral therapy. Several issues related to this complication (prevalence, diagnosis, pathogenesis, prevention, or clinical management) have not been completely clarified. However, in the last years, substantial progress has been made in elucidating some of these basic aspects. This includes a better knowledge of the pathogenic mechanisms underlying HIV/HAART-associated lipodystrophy syndrome such as genetic host determinants, the impact of HIV infection per se, as well as the contribution of antiretroviral therapy. In regard to treatment, we have learned that certain drugs are especially prone to cause HIV/HAART-associated lipodystrophy syndrome (i.e. thymidine analogues). Pharmacological interventions to treat this condition have yielded mostly disappointing results, and the only intervention which offers an immediate aesthetical improvement for patients with HIV/HAART-associated lipodystrophy syndrome is plastic surgery. Even under the most favorable conditions (ideal host genetic make-up, and the timely initiation of HIV therapy with less toxic drugs), current data show that HIV/HAART-associated lipodystrophy syndrome is a complication of HIV infection and/or antiretroviral treatment that we are unable to avoid. In the context of HIV-1-infected patients under long-term antiretroviral therapy, fat toxicity is still the dark side of the rainbow.
人类免疫缺陷病毒相关脂肪营养不良中生长激素动态的评估。
DOI：
10.1210/jcem.86.2.7175
发表时间：
2001
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Rietschel,P;Hadigan,C;Corcoran,C;Stanley,T;Neubauer,G;Gertner,J;Grinspoon,S
通讯作者：
Grinspoon,S
多中心艾滋病队列研究中的人体测量学和检查者报告的身体习惯异常。
DOI：
10.1086/381684
发表时间：
2004
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
影响因子：
--
作者：
PalellaJr,FrankJ;Cole,StephenR;Chmiel,JoanS;Riddler,SharonA;Visscher,Barbara;Dobs,Adrian;Williams,Carolyn
通讯作者：
Williams,Carolyn