Acute RNA Viral Encephalomyelitis and the Role of Antibodies in the Central Nervous System.
Acute RNA Viral Encephalomyelitis and the Role of Antibodies in the Central Nervous System.
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DOI：
10.3390/v12090988
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发表时间：
2020-09-05
期刊：
影响因子：
--
通讯作者：
Griffin DE
中科院分区：
文献类型：
--
作者：
Bartlett ML;Griffin DE
急性RNA病毒性脑脊髓炎是许多病毒感染的严重并发症。脑脊液（CSF）中的抗体与更好的结局相关，并且有大量证据表明抗体分泌细胞（ASC）进入中枢神经系统（CNS）并有助于感染的消退。在这里，我们回顾了已知的RNA病毒引起急性病毒性脑脊髓炎的控制机制，需要抗体或ASC。我们编译的细胞因子，趋化因子和表面受体与ASC招聘感染后的CNS和比较已知的抗体介导的机制，以及潜在的noncytolytic病毒控制机制。抗体的这些非典型功能可用于CNS中以保护珍贵的不可再生神经元。了解中枢神经系统的免疫特化区对于开发RNA病毒引起的急性脑脊髓炎的有效治疗方法至关重要。
Acute RNA viral encephalomyelitis is a serious complication of numerous virus infections. Antibodies in the cerebral spinal fluid (CSF) are correlated to better outcomes, and there is substantive evidence of antibody secreting cells (ASCs) entering the central nervous system (CNS) and contributing to resolution of infection. Here, we review the RNA viruses known to cause acute viral encephalomyelitis with mechanisms of control that require antibody or ASCs. We compile the cytokines, chemokines, and surface receptors associated with ASC recruitment to the CNS after infection and compare known antibody-mediated mechanisms as well as potential noncytolytic mechanisms for virus control. These non-canonical functions of antibodies may be employed in the CNS to protect precious non-renewable neurons. Understanding the immune-specialized zone of the CNS is essential for the development of effective treatments for acute encephalomyelitis caused by RNA viruses.
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