Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study.
Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study.
复制标题
皮质-边缘-小脑白质网络的异常可能导致难治性抑郁症：弥散张量成像研究
DOI：
10.1186/1471-244x-13-72
复制
发表时间：
2013-03-02
期刊：
影响因子：
4.4
通讯作者：
Li LJ
中科院分区：
文献类型：
--
作者：
Peng HJ;Zheng HR;Ning YP;Zhang Y;Shan BC;Zhang L;Yang HC;Liu J;Li ZX;Zhou JS;Zhang ZJ;Li LJ
白质异常可导致网络功能障碍，而这正是重度抑郁症（MDD）的发病基础。弥散张量成像（DTI）用于检测白质的神经连接性和完整性。先前的研究表明，前额叶 - 边缘神经网络与MDD的病理生理机制有关。约30%的MDD患者表现为难治性抑郁症（TRD）。然而，TRD的神经生物学机制仍不明确。
我们采用基于体素的分析方法，对30例（19名男性，11名女性）年轻TRD患者的DTI数据进行分析，并与年龄、性别匹配的25名右利手健康志愿者（14名男性，11名女性）进行对比。
我们发现，在左侧额中回（峰值坐标[-18 46 -14]）、左侧边缘叶钩回（峰值坐标[-18 2 -22]）和右侧小脑后叶（峰值坐标[26 -34 -40]），各向异性分数（FA）显著降低（校正后，簇大小>50）。患者任何脑区的FA均未升高。我们还发现，这三个区域的平均区域FA值与贝克抑郁量表症状评分之间存在显著负相关。
我们发现，TRD患者与对照组在额叶、边缘叶和小脑的白质FA方面存在显著差异。这些数据表明，皮质 - 边缘 - 小脑白质网络的异常可能与年轻患者的TRD发病有关。
BackgroundWhite matter abnormalities can cause network dysfunction that underlies major depressive disorder (MDD). Diffusion tensor imaging (DTI) is used to examine the neural connectivity and integrity of the white matter. Previous studies have implicated frontolimbic neural networks in the pathophysiology of MDD. Approximately 30% of MDD patients demonstrate treatment-resistant depression (TRD). However, the neurobiology of TRD remains unclear.MethodsWe used a voxel-based analysis method to analyze DTI data in young patients with TRD (n = 30; 19 males, 11 females) compared with right-handed, age- and sex-matched healthy volunteers (n = 25; 14 males, 11 females).ResultsWe found a significant decrease in fractional anisotropy (FA) (corrected, cluster size >50) in the left middle frontal gyrus (peak coordinates [−18 46–14]), left limbic lobe uncus (peak coordinates [−18 2–22]), and right cerebellum posterior lobe (peak coordinates [26–34 -40]). There was no increase in FA in any brain region in patients. We also found a significant negative correlation between mean regional FA values in the three areas and Beck Depression Inventory symptom scores.ConclusionsWe found significant differences in white matter FA in the frontal lobe, limbic lobe and cerebellum between TRD patients and controls. These data suggest that abnormalities of cortical-limbic-cerebellar white matter networks may contribute to TRD in young patients.