Synthesis and Fluorescent Properties of Biodegradable Hyperbranched Poly(amido amine)s.
Synthesis and Fluorescent Properties of Biodegradable Hyperbranched Poly(amido amine)s.
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DOI：
10.1002/marc.200900482
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发表时间：
2009-12
影响因子：
4.6
通讯作者：
Wen Yang;C. Pan
中科院分区：
文献类型：
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作者：
Wen Yang;C. Pan
以N，N′-半胺双丙烯酰胺和1-（2-氨基乙基）哌嗪为原料，采用Michael加成聚合法制备了二硫代官能化超支化聚氨基胺（HPAMAMs）。新型HPAMAMs显示出明亮的荧光，其发射波段几乎覆盖了整个可见波长范围。当聚合物溶液在330-385、460-490和510-550 nm处激发时，分别观察到蓝色、绿色和红色溶液。HPAMAMs是可生物降解的，它们很容易被2-巯基乙醇或谷胱甘肽裂解，导致荧光强度降低。生物相容性和可生物降解的hpamam在荧光成像技术和生物科学中的应用研究正在进行中。
Disulfide-functionalized hyperbranched poly(amido amine)s (HPAMAMs) were synthesized by Michael addition polymerization of N,N'-cystaminebisacrylamide and 1-(2-aminoethyl)piperazine. The novel HPAMAMs displayed bright fluorescence, and the emissions bands cover nearly the whole visible wavelength range. When polymer solutions were excited at 330-385, 460-490, and 510-550 nm, blue, green, and red solutions were observed, respectively. The HPAMAMs are biodegradable and they can be easily cleaved by 2-mercaptoethanol or glutathione, leading to a decrease in the fluorescence intensity. Studies of applications of the biocompatible and biodegradable HPAMAMs in fluorescence imaging technology and biological science are in progress.