Novel oxidized sorbicillin dimers with 1,1-diphenyl-2-picrylhydrazyl-radical scavenging activity from a fungus
Novel oxidized sorbicillin dimers with 1,1-diphenyl-2-picrylhydrazyl-radical scavenging activity from a fungus
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DOI：
10.1271/bbb.62.2120
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发表时间：
1998-11-01
影响因子：
1.6
通讯作者：
Hirota, A
中科院分区：
文献类型：
--
作者：
Abe, N;Murata, T;Hirota, A
从土壤中分离的木霉（Trichoderma sp.）USF-2690菌株发酵液中分离得到3个具有1，1-二苯基-2-苦肼基自由基清除活性的黄色化合物，其中2个为新的山梨西林氧化二聚体，分别命名为bisorbicillinerase（1）和bisorbicillinerase（2），1个为山梨西林本身。化合物1和2的结构由谱学证据确定。在DPPH-自由基清除试验中，α-生育酚静置30分钟后的ED 50值为17.0 μ M，白色连续观察表明，双山梨酯、双山梨酯和山梨酯的ED 50值在24小时内缓慢达到80.8、88.8和152.3 μ M。
Three yellowish compounds with 1,1-diphenyl-2-picryl-hydrazyl-radical scavenging activity were newly isolated from the fermentation broth of Trichoderma sp. USF-2690 strain that had been isolated from a soil sample: two were novel oxidized sorbicillin dimers designated as bisorbicillinolide (1) and bisorbicillinolide (2), and one was sorbicillin (3) itself. The structures of 1 and 2 were determined from spectroscopic evidence. In the DPPH-radical scavenging assay, alpha-tocopherol gave an ED50 value of 17.0 mu M after standing for 30 min, white continuing observation showed that the ED50 values for bisorbibutenolide, bisorbicillinolide, and sorbicillin slowly reached 80.8, 88.8 and 152.3 mu M over 24 hr.