Motion-corrected simultaneous cardiac positron emission tomography and coronary MR angiography with high acquisition efficiency
Motion-corrected simultaneous cardiac positron emission tomography and coronary MR angiography with high acquisition efficiency
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DOI：
10.1002/mrm.26690
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发表时间：
2018-01-01
影响因子：
3.3
通讯作者：
Prieto, Claudia
中科院分区：
文献类型：
--
作者：
Munoz, Camila;Neji, Radhouene;Prieto, Claudia
目的在3特斯拉PET- mr系统上建立一种高效的自由呼吸全心冠状动脉磁共振血管造影（CMRA）和心脏正电子发射断层扫描（PET）框架。方法开发了一种能够同时对CMRA和PET进行非刚性运动校正的采集方法。该方法从每次心跳时获取的低分辨率2D MR图像导航器中估计平移运动，从CMRA数据本身估计不同呼吸箱之间的3D非刚性呼吸运动。估计的运动用于校正CMRA以及发射和衰减PET数据集到相同的呼吸位置。在10名健康受试者中研究了CMRA方法，并将左、右冠状动脉（LCA、RCA）与膈导航门控和跟踪的参考扫描进行了比较。PET-CMRA方法在5例F-18-FDG心肌摄取的肿瘤患者中进行了测试。将PET图像与未校正和门控的PET重建图像进行比较。结果健康受试者的血管长度和锐度与导航门控跟踪的参考采集方法比较，差异无统计学意义（P < 0.01），但数据采集时间明显缩短。与不进行运动校正相比，该方法使CMRA血管清晰度分别提高了37.9%和49.1% (LCA， RCA)，血管长度分别提高了48.0%和36.7% （LCA， RCA）。运动校正的PET图像显示，与未校正的重建相比，心肌的清晰度有所提高，与门控重建相比，噪声有所降低。结论证实了一种新型呼吸运动补偿心脏PET-CMRA同步采集方法的可行性。中华医学杂志（英文版），2018。(c) 2017年Wiley期刊公司代表国际医学磁共振学会出版的《医学磁共振》。这是一篇基于知识共享署名许可协议的开放获取文章，该协议允许在任何媒体上使用、分发和复制，前提是正确引用原始作品。
PurposeDevelop a framework for efficient free-breathing simultaneous whole-heart coronary magnetic resonance angiography (CMRA) and cardiac positron emission tomography (PET) on a 3 Tesla PET-MR system.MethodsAn acquisition that enables nonrigid motion correction of both CMRA and PET has been developed. The proposed method estimates translational motion from low-resolution 2D MR image navigators acquired at each heartbeat and 3D nonrigid respiratory motion between different respiratory bins from the CMRA data itself. Estimated motion is used for correcting the CMRA as well as the emission and attenuation PET data sets to the same respiratory position. The CMRA approach was studied in 10 healthy subjects and compared for both left and right coronary arteries (LCA, RCA) against a reference scan with diaphragmatic navigator gating and tracking. The PET-CMRA approach was tested in 5 oncology patients with F-18-FDG myocardial uptake. PET images were compared against uncorrected and gated PET reconstructions.ResultsFor the healthy subjects, no statistically significant differences in vessel length and sharpness (P>0.01) were observed between the proposed approach and the reference acquisition with navigator gating and tracking, although data acquisition was significantly shorter. The proposed approach improved CMRA vessel sharpness by 37.9% and 49.1% (LCA, RCA) and vessel length by 48.0% and 36.7% (LCA, RCA) in comparison with no motion correction for all the subjects. Motion-corrected PET images showed improved sharpness of the myocardium compared to uncorrected reconstructions and reduced noise compared to gated reconstructions.ConclusionFeasibility of a new respiratory motion-compensated simultaneous cardiac PET-CMRA acquisition has been demonstrated. Magn Reson Med 79:339-350, 2018. (c) 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.