Regional Heterogeneity of Length-Tension Relationships in Rat Lymph Vessels
Regional Heterogeneity of Length-Tension Relationships in Rat Lymph Vessels
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DOI：
10.1089/lrb.2011.0013
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发表时间：
2012-01-01
影响因子：
1.4
通讯作者：
Davis, Michael J.
中科院分区：
文献类型：
--
作者：
Gashev, Anatoliy A.;Zhang, Rong-Zhen;Davis, Michael J.
背景资料：淋巴管的长度-张力关系的异质性从来没有被系统地evaluatedsystems.Methods和结果：在这项研究中，我们测量了从三个不同地区的大鼠：胸导管，颈部和股淋巴管的长度-张力关系的淋巴管，并比较我们以前的测量大鼠肠系膜淋巴管的结果。我们使用小血管线肌描记器对激活和被动淋巴管段进行等长力测量。我们发现，所有组的血管在其主动张力与长度的关系中具有相对较宽的平台，这表明它们适于在相对较宽的预载荷范围内（至少0.85-1.05 L-0）产生接近最大的张力。胸导管表现出最平坦的主动张力曲线，特别是对于峰值主动张力，其中从0.75到1.30的最佳长度，峰值主动张力的变化小于5%。股淋巴管能够承受最高的估计压力，其次是肠系膜和颈部血管，然后胸duct.Conclusions：我们的结论是，淋巴管有效地适应其收缩力的特定流体动力学条件（transmartical压力和管腔内流量），存在于不同地区的淋巴系统。
Background: Heterogeneity of the length-tension relationships in lymph vessels has never been evaluated systematically.Methods and Results: In this study we measured the length-tension relationships in lymph vessels from three different regions of the rat: thoracic duct, cervical, and femoral lymph vessels, and compared the results to our previous measurements of rat mesenteric lymph vessels. We performed isometric force measurements on activated and passive lymph vessel segments using a small-vessel wire myograph. We found that all groups of vessels had relatively broad plateaus in their active tension versus length relationships, suggesting that they are adapted to generate near-maximal tensions over a relatively wide range of preloads (at least 0.85-1.05 L-0). Thoracic duct exhibited the flattest active tension curve, particularly for peak active tension, in which there was less than a 5% change in peak active tension from 0.75 to 1.30 of optimal length. Femoral lymph vessels were able to withstand the highest estimated pressures, followed by mesenteric and cervical vessels and then thoracic duct.Conclusions: We conclude that lymph vessels effectively adapt their contractile force to the particular hydrodynamic conditions (transmural pressures and intraluminal flows) that exist in different regions of the lymphatic system.