Spontaneous tumors of NFS mice congenic for ecotropic murine leukemia virus induction loci.
Spontaneous tumors of NFS mice congenic for ecotropic murine leukemia virus induction loci.
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NFS 小鼠的自发性肿瘤与亲嗜性鼠白血病病毒诱导位点同源。
DOI：
10.1093/jnci/73.2.521
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Rowe,WP
中科院分区：
文献类型：
--
作者：
Fredrickson,TN;Morse3rd,HC;Rowe,WP
研究人员对来自AKR和C58小鼠的环保性小鼠白血病病毒（MuLV）诱导位点的NFS/N小鼠（“NFS V-congenics”）自发肿瘤的发生进行了评估，并与病毒阴性的NFS/N小鼠进行了比较。同源小鼠发生胸腺淋巴瘤，而NFS/N小鼠则没有。然而，与AKR/N或C58/Lw小鼠相比，NFS v基因胸腺淋巴瘤的发生频率降低，其发展潜伏期延长。此外，非胸腺淋巴瘤和骨髓性白血病的发生率比NFS/N增加了三倍以上。在遗传动物中，造血肿瘤的频率增加与早期高水平的系统生态性MuLV表达有关。
NFS/N mice congenic for ecotropic murine leukemia virus (MuLV) induction loci from AKR and C58 mice (“NFS V-congenics”) were evaluated for the development of spontaneous neoplasms in comparison to such development in virus-negative NFS/N mice. Congenic mice developed thymic lymphomas, whereas NFS/N did not. However, the frequency of thymic lymphomas was reduced, and the latent period for their development was prolonged in NFS V-congenics as compared to that in AKR/N or C58/Lw mice. In addition, the frequencies of nonthymic lymphomas and myelogenous leukemias were increased more than threefold in the congenics over NFS/N. The increased frequencies of hematopoietic neoplasms in congenic animals were related to early expression of high systemic levels of ecotropic MuLV.